Central pontine myelinolysis after liver transplantation: case report

Central Pontine Myelinolysis (CPM) is a demyelinating disease with central pontine localization which presents in patients with chronic hepatic disease and hydroelectrolytic disturbances. In spite of pathophysiology still unknown, the patient liver transplanted has several risk factors to CPM. Its c...

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Bibliographic Details
Published in:Acta Neurológica Colombiana 2017-01, Vol.33 (3), p.154-159
Main Authors: Silva Sieger, Federico A, Serrano-Martínez, Adriana M., Castillo, Alberto, Vanegas Ballesteros, Mauricio, Cote Florez, Tania Paola
Format: Article
Language:English
Subjects:
Central pontine myelinolysis
critical care
hepatic encephalopathy
hydroelectrolitic disturbances
immunosuppressants
liver transplantation
MEDICINE, GENERAL & INTERNAL
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Summary:Central Pontine Myelinolysis (CPM) is a demyelinating disease with central pontine localization which presents in patients with chronic hepatic disease and hydroelectrolytic disturbances. In spite of pathophysiology still unknown, the patient liver transplanted has several risk factors to CPM. Its clinical manifestations are mainly motor and awareness alterations. Diagnosis requires brain images like magnetic resonance and it has a poor prognosis in critical care patients and it is very important to know about the possibility of presentation and to be aware about this pathology. The main objective to present this case report is sensitizing the medical community regarding the CPM in patients with liver transplant. The case report of a 40-year-old female patient who had previous history of biliary cirrhosis secondary to autoimmune hepatitis and liver transplantation was performed; subsequently developed alteration of awareness, hydroelectrolytic disturbances and abnormal findings in brain imaging. CPM is a neurological demyelinating disease with multifactorial origin, its treatment is supportive and prevention is the main goal in patients with risk factors like patient after liver transplantation.
ISSN:0120-8748
2422-4022
DOI:10.22379/24224022150