Vitamin D3 Supplementation: Comparison of 1000 IU and 2000 IU Dose in Healthy Individuals

• Published in: Life (Basel, Switzerland) Switzerland), 2023-03, Vol.13 (3), p.808
• Main Authors: Dědečková, Eva, Viták, Roman, Jirásko, Michal, Králová, Markéta, Topolčan, Ondřej, Pecen, Ladislav, Fürst, Tomáš, Brož, Pavel, Kučera, Radek
• Format: Article
• Language: English
• Subjects: Calciferol; Dietary supplements; Drug dosages; Metabolism; Metabolites; Rickets; serum level; Serum levels; Skin; supplementation; Supplements; Ultraviolet radiation; Vitamin D; vitamin D deficiency; vitamin D insufficiency; Vitamin D3; Vitamin deficiency; Winter
• ISSN: 2075-1729; 2075-1729
• DOI: 10.3390/life13030808

Background: Scientific studies point to a significant global vitamin D deficiency. The recommended dose of vitamin D for the adult population in Central Europe is 800–2000 IU/day. The aim of our study was to determine whether doses of 1000 IU or 2000 IU of vitamin D3 are adequate to achieve the sufficiency reference values of [25(OH)D]. Methods: Seventy-two healthy volunteers, average age twenty-two, took part in the study. The study was conducted from October to March in order to eliminate intra-dermal vitamin D production. Vitamin D3 in an oleaginous mixture was used. The participants used either 1000 IU or 2000 IU/daily for two 60-day periods with a 30-day break. Results: The dose of 1000 IU, taken for 60 days, increased vitamin D levels relatively little. Furthermore, serum vitamin D levels decreased in the 30 days following the cessation of supplementation. Taking 2000 IU daily led to a sharp increase in serum levels which plateaued 30 days after the subjects stopped using vitamin D3 drops. Conclusions: Both doses, taken daily, can help maintain adequate vitamin D levels during the winter months. A daily dose of 2000 IU, however, maintained the desired levels of vitamin D for a longer period.