Diagnosis of fish and shellfish allergies

Seafood allergy is a hypersensitive disorder with increasing prevalence worldwide. Effective and accurate diagnostic workup for seafood allergy is essential for clinicians and patients. Parvalbumin and tropomyosin are the most common fish and shellfish allergens, respectively. The diagnosis of seafo...

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Bibliographic Details
Published in:Journal of asthma and allergy 2018-01, Vol.11, p.247-260
Main Authors: Tong, Wai Sze, Yuen, Agatha Wt, Wai, Christine Yy, Leung, Nicki Yh, Chu, Ka Hou, Leung, Patrick Sc
Format: Article
Language:English
Subjects:
Agriculture
Algorithms
Allergens
Allergies
Allergy
Allergy tests
Antigenic determinants
Cloning
Cod
Component-resolved diagnosis
Cross-reactivity
DBPCFC
Diagnosis
Epitopes
Fish
Fishing
Food allergies
Identification
ImmunoCAP
Immunoglobulin E
Immunology
ISAC
Medical diagnosis
Medical research
Medical tests
Muscle proteins
Parvalbumin
Patient compliance
Proteins
Review
Seafood
Shellfish
Skin
Skin prick test
Skin tests
Tropomyosin
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Summary:Seafood allergy is a hypersensitive disorder with increasing prevalence worldwide. Effective and accurate diagnostic workup for seafood allergy is essential for clinicians and patients. Parvalbumin and tropomyosin are the most common fish and shellfish allergens, respectively. The diagnosis of seafood allergies is complicated by cross-reactivity among fish allergens and between shellfish allergens and other arthropods. Current clinical diagnosis of seafood allergy is a complex algorithm that includes clinical assessment, skin prick test, specific IgE measurement, and oral food challenges. Emerging diagnostic strategies, such as component-resolved diagnosis (CRD), which uses single allergenic components for assessment of epitope specific IgE, can provide critical information in predicting individualized sensitization patterns and risk of severe allergic reactions. Further understanding of the molecular identities and characteristics of seafood allergens can advance the development of CRD and lead to more precise diagnosis and improved clinical management of seafood allergies.
ISSN:1178-6965
1178-6965
DOI:10.2147/JAA.S142476