CT-derived 3D-diaphragm motion in emphysema and IPF compared to normal subjects

• Published in: Scientific reports 2021-07, Vol.11 (1), p.14923-14923, Article 14923
• Main Authors: Kang, Ji Hee, Choi, Jiwoong, Chae, Kum Ju, Shin, Kyung Min, Lee, Chang-Hoon, Guo, Junfeng, Lin, Ching-Long, Hoffman, Eric A., Lee, Changhyun
• Format: Article
• Language: English
• Subjects: 631/57/2266; 639/766/747; 692/699/1785; Adult; Aged; Aged, 80 and over; Computed tomography; Diaphragm; Emphysema; Female; Fibrosis; Healthy Volunteers; Humanities and Social Sciences; Humans; Idiopathic Pulmonary Fibrosis - diagnostic imaging; Image processing; Imaging, Three-Dimensional - methods; Lung - diagnostic imaging; Lung diseases; Lung Volume Measurements; Male; Middle Aged; multidisciplinary; Pulmonary Emphysema - diagnostic imaging; Registration; Science; Science (multidisciplinary); Tomography, X-Ray Computed - methods; Young Adult
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-93980-5

Image registration-based local displacement analysis enables evaluation of respiratory motion between two computed tomography-captured lung volumes. The objective of this study was to compare diaphragm movement among emphysema, idiopathic pulmonary fibrosis (IPF) and normal subjects. 29 normal, 50 emphysema, and 51 IPF subjects were included. A mass preserving image registration technique was used to compute displacement vectors of local lung regions at an acinar scale. Movement of the diaphragm was assumed to be equivalent to movement of the basal lung within 5 mm from the diaphragm. Magnitudes and directions of displacement vectors were compared between the groups. Three-dimensional (3D) and apico-basal displacements were smaller in emphysema than normal subjects ( P  = 0.003, P  = 0.002). Low lung attenuation area on expiration scan showed significant correlations with decreased 3D and apico-basal displacements (r = − 0.546, P