Impact of ursodeoxycholic acid on circulating lipid concentrations: a systematic review and meta-analysis of randomized placebo-controlled trials

The aim of this meta-analysis of randomized placebo-controlled trials was to examine whether ursodeoxycholic acid treatment is an effective lipid-lowering agent. PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases were searched in order to find randomized controlled trials evaluating...

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Bibliographic Details
Published in:Lipids in health and disease 2019-04, Vol.18 (1), p.88-88, Article 88
Main Authors: Simental-Mendía, Luis E, Simental-Mendía, Mario, Sánchez-García, Adriana, Banach, Maciej, Serban, Maria-Corina, Cicero, Arrigo F G, Sahebkar, Amirhossein
Format: Article
Language:English
Subjects:
Acids
Analysis
Anticholesteremic agents
Bile
Biliary cirrhosis
Cardiovascular disease
Care and treatment
Cholesterol
Cirrhosis
Clinical trials
Data processing
Dyslipidemias
Generic drugs
HDL
High density lipoprotein
LDL
Lipid profile
Lipids
Liver cirrhosis
Low density lipoprotein
Low density lipoproteins
Meta-analysis
Patients
Placebos
Prevalence studies (Epidemiology)
Primary biliary cirrhosis
Review
Sensitivity analysis
Systematic review
Total cholesterol
Triglycerides
Type 2 diabetes
Ursodeoxycholic acid
Ursodiol
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Summary:The aim of this meta-analysis of randomized placebo-controlled trials was to examine whether ursodeoxycholic acid treatment is an effective lipid-lowering agent. PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases were searched in order to find randomized controlled trials evaluating the effect of ursodeoxycholic acid on lipid profile. A random-effect model and the generic inverse variance weighting method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. A random-effects meta-regression model was performed to explore the association between potential confounders and the estimated effect size on plasma lipid concentrations. Meta-analysis of 20 treatment arms revealed a significant reduction of total cholesterol following ursodeoxycholic acid treatment (WMD: - 13.85 mg/dL, 95% CI: -21.45, - 6.25, p 
ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-019-1041-4