Monobutyrin and monovalerin improve gut–blood–brain biomarkers and alter gut microbiota composition in high-fat fed apolipoprotein-E-knockout rats

Monobutyrin (MB) and monovalerin (MV), glycerol esters of short-chain fatty acids (SCFAs), have been shown to positively influence lipid profile and biomarkers in the gut and brain. This study examined whether MB and MV in high-fat diets, affected microbiota composition and gut–blood–brain markers i...

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Bibliographic Details
Published in:Scientific reports 2022-09, Vol.12 (1), p.15454-11, Article 15454
Main Authors: Nguyen, Thao Duy, Watanabe, Ayako, Burleigh, Stephen, Ghaffarzadegan, Tannaz, Kanklai, Jirapat, Prykhodko, Olena, Hållenius, Frida Fåk, Nyman, Margareta
Format: Article
Language:English
Subjects:
631/326/2565/2134
631/45/287/1183
692/617/375/365/1283
Alzheimer's disease
Animals
Apolipoprotein E
Apolipoproteins
Apolipoproteins E
Biomarkers
Blood
Blood-Brain Barrier
Brain research
Cholic acid
Corticosterone
Diet
Dietary supplements
Discriminant analysis
Esters
Fatty acids
Fatty Acids, Volatile
Gastrointestinal Microbiome
Glycerides
Glycerol
Health Sciences
High fat diet
Humanities and Social Sciences
Hälsovetenskap
Intestinal microflora
Lipids
Medical and Health Sciences
Medicin och hälsovetenskap
Microbiota
multidisciplinary
Neurodegenerative diseases
Nutrition and Dietetics
Nutrition research
Näringslära
Rats
Rodents
Science
Science (multidisciplinary)
Taxonomy
Variance analysis
γ-Aminobutyric acid
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Summary:Monobutyrin (MB) and monovalerin (MV), glycerol esters of short-chain fatty acids (SCFAs), have been shown to positively influence lipid profile and biomarkers in the gut and brain. This study examined whether MB and MV in high-fat diets, affected microbiota composition and gut–blood–brain markers in apolipoprotein E deficient (ApoE-/-) rats, a model for studies of lipid-associated disorders, and neurodegenerative processes in Alzheimer’s disease (AD). ApoE-/- rats fed MB and MV increased Tenericutes and the brain neurotransmitter γ-aminobutyric acid (GABA), while the blood stress hormone corticosterone decreased compared to control rats. Only rats that received MB showed a significant increase in cholic acid and Adlercreutzia in the caecum. In rats fed MV, the decrease of Proteobacteria was associated with decreased corticosterone levels. Conclusively, dietary supplementation of SCFA glycerol esters can modulate gut–blood–brain markers and alter gut microbiota composition in ApoE-/- rats, suggesting that SCFAs also could counteract lipid disorders-related diseases.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-19502-z