The Role of CD8A in the Immune Microenvironment of Breast Cancer

Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer (BC), and it is often associated with a high tumor grade, a younger age at diagnosis, and a low survival rate. Conventional endocrine and anti-HER-2 therapies are usually ineffective against TNBC, creating treatment challeng...

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Bibliographic Details
Published in:Frontiers in bioscience (Landmark. Print) 2024-02, Vol.29 (2), p.73-73
Main Authors: Chu, Jian, Tang, Shan, Li, Tangya, Fan, Huiwen
Format: Article
Language:English
Subjects:
breast cancer
differentially expressed genes
Down-Regulation
Gene Expression
Humans
Lung Neoplasms
Oncogenes
Triple Negative Breast Neoplasms - genetics
triple-negative breast cancer
tumor immune microenvironment
Tumor Microenvironment - genetics
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Summary:Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer (BC), and it is often associated with a high tumor grade, a younger age at diagnosis, and a low survival rate. Conventional endocrine and anti-HER-2 therapies are usually ineffective against TNBC, creating treatment challenges and resulting in a poor prognosis. Hence, new targets and treatment strategies for TNBC are urgently required. The GSE102818 dataset was used to identify differentially expressed genes (DEGs) between primary BC and metastatic BC lesions. The Cancer Genome Atlas and the cBioPortal platform were employed to explore mutations in candidate genes. Utilizing the Tumor IMmune Estimation Resource (TIMER), the relationship between the expression of candidate genes and immune cell infiltration was assessed. Additionally, the cell-specific expression of the candidate genes was examined in the immune microenvironment of primary BC and metastatic BC lesions using the single-cell RNA sequencing (scRNA-seq) datasets GSE118389 and GSE202695. Finally, the protein expression of the candidate genes in clinical TNBC samples was evaluated. was identified as a hub gene in the DEG network and was found to be down-regulated in metastatic BC lesions. expression was highly correlated with the infiltration of CD8+ T cells, and elevated expression was correlated with improved survival. Interestingly, scRNA-seq data revealed that was down-regulated in CD8+ T cells in the immune microenvironment of metastatic BC lesions. Finally, the evaluation of clinical samples confirmed the down-regulation of in the immune microenvironment of BC lung metastases. In patients with metastatic TNBC, high levels of (especially in the immune microenvironment) are associated with a good prognosis.
ISSN:2768-6701
2768-6698
DOI:10.31083/j.fbl2902073