Immunohistochemical Expression of Xenophagy Proteins in Helicobacter pylori and None Helicobacter pylori Gastritis

The complex interplay between H. pylori and autophagy was elucidated in gastritis in term of host defense and survival of microbe. However, H. pylori frequently succeed in their survival and develops more aggressive tissue damage by different ways. A total of 80 gastritis patients undergoing gastros...

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Bibliographic Details
Published in:Journal of pure & applied microbiology : an international research journal of microbiology 2018-12, Vol.12 (4), p.1795-1800
Main Authors: Ghazi, Haider F, Fahad, Hayfaa M, Mahmood, Aqeel S, Qasim, Ban J
Format: Article
Language:English
Subjects:
Autophagy (Cytology)
Formaldehyde
Gastritis
Gastrointestinal diseases
h. pylori
Helicobacter infections
Helicobacter pylori
Hydrolases
Immunoglobulin G
Immunohistochemistry
Medical schools
Microbiological research
Physiological aspects
Proteins
xenophagy
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Summary:The complex interplay between H. pylori and autophagy was elucidated in gastritis in term of host defense and survival of microbe. However, H. pylori frequently succeed in their survival and develops more aggressive tissue damage by different ways. A total of 80 gastritis patients undergoing gastroscopy during September, 2013 to August, 2014. Formalin fixed paraffin embedded gastric tissue were prepared for immunohistochemistry evaluation of ATG16L1, LC3C and vacA protein expression. Rapid urease test was used to discriminate between H. pylori or none H. pylori gastritis. Xenophagy index was elevated among both urease and IgG positive cases (29.86% and 27.13%) compared with negative cases (13.43% and 17.6% respectively (p
ISSN:0973-7510
2581-690X
DOI:10.22207/JPAM.12.4.12