Dissolving Triamcinolone-Embedded Microneedles for the Treatment of Keloids: A Single-Blinded Intra-Individual Controlled Clinical Trial

Introduction Keloids are a prevalent chronic skin disorder with significant psychosocial morbidity. Intralesional corticosteroid injections are the first-line treatment but are painful and require repeated injections by medical professionals. Dissolving microneedles are a novel method of cutaneous d...

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Bibliographic Details
Published in:Dermatology and therapy 2019-09, Vol.9 (3), p.601-611
Main Authors: Tan, Colin W. X., Tan, Wei Ding, Srivastava, Ruchir, Yow, Ai Ping, Wong, Damon W. K., Tey, Hong Liang
Format: Article
Language:English
Subjects:
Care and treatment
Clinical trials
Dermatology
Diagnosis
Dosage and administration
Drug delivery systems
Evidence-based medicine
Hypodermic needles
Internal Medicine
Keloids
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Microneedle drug delivery
Microneedles
Oral and Maxillofacial Surgery
Original Research
Plastic Surgery
Quality of Life Research
Scars
Skin diseases
Testing
Triamcinolone
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Summary:Introduction Keloids are a prevalent chronic skin disorder with significant psychosocial morbidity. Intralesional corticosteroid injections are the first-line treatment but are painful and require repeated injections by medical professionals. Dissolving microneedles are a novel method of cutaneous drug delivery that induces minimal/no pain and can be self-administered. The objective of the study was to evaluate the efficacy and safety of triamcinolone-embedded dissolving microneedles in treatment of keloids. Methods This was a single-blind, intra-individual controlled two-phase clinical trial of 8-week duration each. Two keloids per subject were selected for (1) once-daily 2-min application with microneedles for 4 weeks, followed by no treatment for the next 4 weeks, or (2) non-intervention as control. Primary outcome was change in keloid volume as assessed by a high-resolution 3D scanner. Results There was significant reduction in keloid volume compared with controls after 4 weeks of treatment. This reduction was greater with a higher dosage of triamcinolone used. Conclusions Once-daily application of dissolving triamcinolone-embedded microneedles significantly reduced the volume of keloids. The treatment was safe, can be self-administered and can serve as an alternative for patients unsuitable for conventional treatments. Trial Registration Trial Registry: Health Science Authority (Singapore) Clinical Trials Register Registration number: 2015/00440.
ISSN:2193-8210
2190-9172
DOI:10.1007/s13555-019-00316-3