Animal Models of C-Reactive Protein

As the main theme of this special issue, CRP not only is an inflammatory marker but also has diverse biological functions associated with different diseases. To investigate CRP’s physiologies and their relationship with human pathological significance, it is essential to use appropriate animal model...

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Bibliographic Details
Published in:Mediators of Inflammation 2014-01, Vol.2014 (6), p.461-467
Main Authors: Torzewski, Michael, Fan, Jianglin, Waqar, Ahmed Bilal
Format: Article
Language:English
Subjects:
Animals
Biomarkers - metabolism
C-reactive protein
C-Reactive Protein - genetics
C-Reactive Protein - metabolism
Genetic aspects
Genetic translation
Health aspects
Humans
Identification and classification
Inflammation
Mice
Mice, Transgenic
Models, Animal
Rabbits
Review
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Summary:As the main theme of this special issue, CRP not only is an inflammatory marker but also has diverse biological functions associated with different diseases. To investigate CRP’s physiologies and their relationship with human pathological significance, it is essential to use appropriate animal models for translational research. The most popular models for the study of CRP are transgenic mice. However, researchers should be careful when extrapolating the findings derived from these animal models. This review will discuss the current concerns on CRP transgenic mice and rabbits.
ISSN:0962-9351
1466-1861
DOI:10.1155/2014/683598