Associations between SII, SIRI, and cardiovascular disease in obese individuals: a nationwide cross-sectional analysis

• Published in: Frontiers in cardiovascular medicine 2024-08, Vol.11, p.1361088
• Main Authors: Liu, Zhou, Zheng, Longxuan
• Format: Article
• Language: English
• Subjects: cardiovascular diseases; Cardiovascular Medicine; inflammation; obesity; prevalence; systemic immune-inflammation index; systemic inflammation response index
• ISSN: 2297-055X; 2297-055X
• DOI: 10.3389/fcvm.2024.1361088

Systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) are comprehensive markers of inflammatory status. However, the correlation between SII and SIRI and the prevalence of cardiovascular disease (CVD) in populations with obesity remains unknown. This is a cross-sectional study with data obtained from the National Health and Nutrition Examination Survey from 1999 to 2018. SII and SIRI were calculated using the following equations: SII = (platelet count × neutrophil count)/lymphocyte count. SIRI = (neutrophil count × monocyte count)/lymphocyte count. Spearman's rank correlation coefficient was used to assess the relationship between SII and SIRI and baseline variables. Logistic regression models and generalized additive model (GAM) with a spline smoothing function were used to evaluate the association between SIRI and CVD prevalence. Nomogram and receiver operating characteristic curve (ROC) analysis were used to assess the value of the risk prediction model. A total of 17,261 participants with obesity and SII and SIRI publicly available data were used for this study. Multivariate logistic regression analysis revealed that SIRI, rather than SII, was an independent risk factor for CVD prevalence. For every standard deviation increase in SIRI, there was a 13%, 15%, and 28% increase in the odds ratios of CVD prevalence (OR = 1.13, 95% CI: 1.04-1.22,  = 0.01), coronary heart disease (OR = 1.15, 95% CI: 1.05-1.26,  = 0.002), and congestive heart failure (OR = 1.28, 95% CI: 1.16-1.41,