High platelet distribution width can independently predict testicular survival in testicular torsion among patients with steady-state sickle cell anemia

ObjectiveThis study aimed to evaluate the predictive value of platelet volume indices (PVI), such as mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT), as prognostic indicators of testicular viability in torsion patients with steady-state sickle cell anemia (SCA)...

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Published in:World journal of pediatric surgery 2022-01, Vol.5 (1), p.e000358-e000358
Main Authors: Adawi, Essa A, Ghanem, Mazen Ahmed, Ghanem, Ahmed Mazen, Safan, Manal A, Elsayed, Mohamed G, Aqeel, Mohammed A
Format: Article
Language:English
Subjects:
Atrophy
biochemistry
Blood
Blood platelets
Disease
Erythema
Hematology
Original Research
Pain
Patients
pediatrics
Sickle cell anemia
Surgery
Testes
Ultrasonic imaging
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cited_by cdi_FETCH-LOGICAL-b457t-ef73006e7044d2fcaad5709302105f4d40aaa00d24095c5cd907e39d99b03a833
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creator Adawi, Essa A
Ghanem, Mazen Ahmed
Ghanem, Ahmed Mazen
Safan, Manal A
Elsayed, Mohamed G
Aqeel, Mohammed A
description ObjectiveThis study aimed to evaluate the predictive value of platelet volume indices (PVI), such as mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT), as prognostic indicators of testicular viability in torsion patients with steady-state sickle cell anemia (SCA) who underwent surgical exploration.MethodsForty-eight patients with SCA with testicular torsion and 46 male control subjects were enrolled in the study. All patients underwent scrotal color Doppler ultrasonography before surgery, and PVI (MPV, PDW, and PCT) values were measured in all participants. Symptom duration and testicular volume were also recorded.ResultsThe testicular salvage rate in patients with SCA was 73% after surgery. Analyses showed that MPV, PDW, and PCT values were significantly higher in torsed SCA as compared with controls (p
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All patients underwent scrotal color Doppler ultrasonography before surgery, and PVI (MPV, PDW, and PCT) values were measured in all participants. Symptom duration and testicular volume were also recorded.ResultsThe testicular salvage rate in patients with SCA was 73% after surgery. Analyses showed that MPV, PDW, and PCT values were significantly higher in torsed SCA as compared with controls (p&lt;0.05). Orchiectomy in patients with SCA showed significantly higher MPV, PDW, and PCT values than the orchiopexy group (p&lt;0.05). The MPV values of orchiectomy patients showed a higher significant cut-off of ≥11.5 fL, which is higher than in torsed patients without SCA, as an indicator of testis survival. PDW also demonstrated a higher significant cut-off of ≥12.7 fL for detorsion outcomes in patients with SCA. Symptom duration of less than 7 hours was also significantly correlated with orchiopexy (p≤0.001). Univariate analysis showed that higher MPV, increased PDW, and symptom duration were indicative of the outcome of testicular detorsion in SCA. Multivariable analysis showed that increased PDW and symptom duration are prognostic parameters for testicular viability in SCA.ConclusionIncreased PDW and symptom duration can be used as parameters for predicting testicular detorsion outcomes in patients with steady-state SCA.</description><identifier>ISSN: 2516-5410</identifier><identifier>ISSN: 2096-6938</identifier><identifier>EISSN: 2516-5410</identifier><identifier>DOI: 10.1136/wjps-2021-000358</identifier><identifier>PMID: 36474627</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd</publisher><subject>Atrophy ; biochemistry ; Blood ; Blood platelets ; Disease ; Erythema ; Hematology ; Original Research ; Pain ; Patients ; pediatrics ; Sickle cell anemia ; Surgery ; Testes ; Ultrasonic imaging</subject><ispartof>World journal of pediatric surgery, 2022-01, Vol.5 (1), p.e000358-e000358</ispartof><rights>Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2022 Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b457t-ef73006e7044d2fcaad5709302105f4d40aaa00d24095c5cd907e39d99b03a833</citedby><cites>FETCH-LOGICAL-b457t-ef73006e7044d2fcaad5709302105f4d40aaa00d24095c5cd907e39d99b03a833</cites><orcidid>0000-0002-2412-7212</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://wjps.bmj.com/content/5/1/e000358.full.pdf$$EPDF$$P50$$Gbmj$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://wjps.bmj.com/content/5/1/e000358.full$$EHTML$$P50$$Gbmj$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793,55350,77660,77686</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36474627$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adawi, Essa A</creatorcontrib><creatorcontrib>Ghanem, Mazen Ahmed</creatorcontrib><creatorcontrib>Ghanem, Ahmed Mazen</creatorcontrib><creatorcontrib>Safan, Manal A</creatorcontrib><creatorcontrib>Elsayed, Mohamed G</creatorcontrib><creatorcontrib>Aqeel, Mohammed A</creatorcontrib><title>High platelet distribution width can independently predict testicular survival in testicular torsion among patients with steady-state sickle cell anemia</title><title>World journal of pediatric surgery</title><addtitle>World Jnl Ped Surgery</addtitle><addtitle>World J Pediatr Surg</addtitle><description>ObjectiveThis study aimed to evaluate the predictive value of platelet volume indices (PVI), such as mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT), as prognostic indicators of testicular viability in torsion patients with steady-state sickle cell anemia (SCA) who underwent surgical exploration.MethodsForty-eight patients with SCA with testicular torsion and 46 male control subjects were enrolled in the study. All patients underwent scrotal color Doppler ultrasonography before surgery, and PVI (MPV, PDW, and PCT) values were measured in all participants. Symptom duration and testicular volume were also recorded.ResultsThe testicular salvage rate in patients with SCA was 73% after surgery. Analyses showed that MPV, PDW, and PCT values were significantly higher in torsed SCA as compared with controls (p&lt;0.05). Orchiectomy in patients with SCA showed significantly higher MPV, PDW, and PCT values than the orchiopexy group (p&lt;0.05). The MPV values of orchiectomy patients showed a higher significant cut-off of ≥11.5 fL, which is higher than in torsed patients without SCA, as an indicator of testis survival. PDW also demonstrated a higher significant cut-off of ≥12.7 fL for detorsion outcomes in patients with SCA. Symptom duration of less than 7 hours was also significantly correlated with orchiopexy (p≤0.001). Univariate analysis showed that higher MPV, increased PDW, and symptom duration were indicative of the outcome of testicular detorsion in SCA. 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Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>World journal of pediatric surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adawi, Essa A</au><au>Ghanem, Mazen Ahmed</au><au>Ghanem, Ahmed Mazen</au><au>Safan, Manal A</au><au>Elsayed, Mohamed G</au><au>Aqeel, Mohammed A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High platelet distribution width can independently predict testicular survival in testicular torsion among patients with steady-state sickle cell anemia</atitle><jtitle>World journal of pediatric surgery</jtitle><stitle>World Jnl Ped Surgery</stitle><addtitle>World J Pediatr Surg</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>5</volume><issue>1</issue><spage>e000358</spage><epage>e000358</epage><pages>e000358-e000358</pages><issn>2516-5410</issn><issn>2096-6938</issn><eissn>2516-5410</eissn><abstract>ObjectiveThis study aimed to evaluate the predictive value of platelet volume indices (PVI), such as mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT), as prognostic indicators of testicular viability in torsion patients with steady-state sickle cell anemia (SCA) who underwent surgical exploration.MethodsForty-eight patients with SCA with testicular torsion and 46 male control subjects were enrolled in the study. All patients underwent scrotal color Doppler ultrasonography before surgery, and PVI (MPV, PDW, and PCT) values were measured in all participants. Symptom duration and testicular volume were also recorded.ResultsThe testicular salvage rate in patients with SCA was 73% after surgery. Analyses showed that MPV, PDW, and PCT values were significantly higher in torsed SCA as compared with controls (p&lt;0.05). Orchiectomy in patients with SCA showed significantly higher MPV, PDW, and PCT values than the orchiopexy group (p&lt;0.05). The MPV values of orchiectomy patients showed a higher significant cut-off of ≥11.5 fL, which is higher than in torsed patients without SCA, as an indicator of testis survival. PDW also demonstrated a higher significant cut-off of ≥12.7 fL for detorsion outcomes in patients with SCA. Symptom duration of less than 7 hours was also significantly correlated with orchiopexy (p≤0.001). Univariate analysis showed that higher MPV, increased PDW, and symptom duration were indicative of the outcome of testicular detorsion in SCA. Multivariable analysis showed that increased PDW and symptom duration are prognostic parameters for testicular viability in SCA.ConclusionIncreased PDW and symptom duration can be used as parameters for predicting testicular detorsion outcomes in patients with steady-state SCA.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd</pub><pmid>36474627</pmid><doi>10.1136/wjps-2021-000358</doi><orcidid>https://orcid.org/0000-0002-2412-7212</orcidid><oa>free_for_read</oa></addata></record>
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source BMJ Journals (Open Access); PubMed Central
subjects Atrophy
biochemistry
Blood
Blood platelets
Disease
Erythema
Hematology
Original Research
Pain
Patients
pediatrics
Sickle cell anemia
Surgery
Testes
Ultrasonic imaging
title High platelet distribution width can independently predict testicular survival in testicular torsion among patients with steady-state sickle cell anemia
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