Cavernosal Smooth Muscle Function After Experimental Ischemic Priapism

Objective: We aimed to investigate the role of apoptosis and its effects on cavernosal smoothmuscle (CSM) function after ischemic priapism (IP) in a rat model. Materials and Methods: Twelve adult Sprague-Dawley rats were assigned into two groups: The priapism and control groups. In all rats, erectio...

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Bibliographic Details
Published in:Journal of urological surgery 2024-06, Vol.11 (2), p.99-104
Main Authors: Hasirci, Eray, Kervancioglu, Enis, Ozer, Cevahir, Erdem, S. Remzi, Goren, Mehmet Resit
Format: Article
Language:English
Subjects:
Apoptosis
Endothelium
erectile function
ischemic priapism
Nitric oxide
Priapism
Smooth muscle
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Summary:Objective: We aimed to investigate the role of apoptosis and its effects on cavernosal smoothmuscle (CSM) function after ischemic priapism (IP) in a rat model. Materials and Methods: Twelve adult Sprague-Dawley rats were assigned into two groups: The priapism and control groups. In all rats, erections were obtained by the vacuum method; however, in the priapism group, erections were maintained with a rubber band for 4 h to mimic priapism. After 14 days following this procedure, penile excision was performed and cavernosal tissues were investigated pharmacologically and histopathologically. Isometric tension changes due to several contractile and relaxant pharmacological agents were investigated with/without nitric oxide synthase (NOS) and guanylate cyclase (GC) inhibition. Results: Isometric contraction and relaxation responses due to the agents applied did not differ between the groups. However, with NOS and GC inhibition, the cavernosal tissues relaxed less in the priapism group than in the controls (p
ISSN:2148-9580
2148-9580
DOI:10.4274/jus.galenos.2023.2023-7-8