Long-Term Sheep Implantation of WIMAGINE ® , a Wireless 64-Channel Electrocorticogram Recorder

• Published in: Frontiers in neuroscience 2019-08, Vol.13, p.847-847
• Main Authors: Sauter-Starace, F, Ratel, D, Cretallaz, C, Foerster, M, Lambert, A, Gaude, C, Costecalde, T, Bonnet, S, Charvet, G, Aksenova, T, Mestais, C, Benabid, Alim-Louis, Torres-Martinez, N
• Format: Article
• Language: English
• Subjects: Animal models; Animals; Brain; brain–computer interface; Clinical trials; Communication; Computer applications; Dura mater; electrocorticogram (ECoG); Electrodes; Electroencephalography; Engineering Sciences; Implants; local tolerance; long-term implantation; Medical research; Neuroscience; Patient safety; Power supply; Preservation; Sheep; signal quality; Somatosensory cortex; Transplants & implants; wireless communications
• ISSN: 1662-4548; 1662-453X; 1662-453X
• DOI: 10.3389/fnins.2019.00847

This article deals with the long-term preclinical validation of WIMAGINE (Wireless Implantable Multi-channel Acquisition system for Generic Interface with Neurons), a 64-channel wireless implantable recorder that measures the electrical activity at the cortical surface (electrocorticography, ECoG). The WIMAGINE implant was designed for chronic wireless neuronal signal acquisition, to be used e.g., as an intracranial Brain-Computer Interface (BCI) for severely motor-impaired patients. Due to the size and shape of WIMAGINE , sheep appeared to be the best animal model on which to carry out long-term validation. The devices were implanted in two sheep for a follow-up period of 10 months, including idle state cortical recordings and Somato-Sensory Evoked Potential (SSEP) sessions. ECoG and SSEP demonstrated relatively stable behavior during the 10-month observation period. Information recorded from the SensoriMotor Cortex (SMC) showed an SSEP phase reversal, indicating the cortical site of the sensorimotor activity was retained after 10 months of contact. Based on weekly recordings of raw ECoG signals, the effective bandwidth was in the range of 230 Hz for both animals and remarkably stable over time, meaning preservation of the high frequency bands valuable for decoding of the brain activity using BCIs. The power spectral density (in dB/Hz), on a log scale, was of the order of 2.2, -4.5 and -18 for the frequency bands (10-40), (40-100), and (100-200) Hz, respectively. The outcome of this preclinical work is the first long-term validation of the WIMAGINE implant, highlighting its ability to record the brain electrical activity through the dura mater and to send wireless digitized data to the external base station. Apart from local adhesion of the dura to the skull, the neurosurgeon did not face any difficulty in the implantation of the WIMAGINE device and post-mortem analysis of the brain revealed no side effect related to the implantation. We also report on the reliability of the system; including the implantable device, the antennas module and the external base station.