A comprehensive excitatory input map of the striatum reveals novel functional organization

The striatum integrates excitatory inputs from the cortex and the thalamus to control diverse functions. Although the striatum is thought to consist of sensorimotor, associative and limbic domains, their precise demarcations and whether additional functional subdivisions exist remain unclear. How st...

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Bibliographic Details
Published in:eLife 2016-11, Vol.5
Main Authors: Hunnicutt, Barbara J, Jongbloets, Bart C, Birdsong, William T, Gertz, Katrina J, Zhong, Haining, Mao, Tianyi
Format: Article
Language:English
Subjects:
Animals
Basal ganglia
Brain
Brain Mapping
Corpus Striatum - anatomy & histology
Corpus Striatum - physiology
corticostriatal projections
Data analysis
Datasets
Functional morphology
mesoscopic connectome
Mice
Neostriatum
Neural circuitry
Neuroscience
Observations
Optogenetics
Perceptual-motor processes
Physiological aspects
Sensorimotor system
Software
striatal circuitry
striatal subdivisions
Striatum
thalamostriatal projections
Thalamus
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Summary:The striatum integrates excitatory inputs from the cortex and the thalamus to control diverse functions. Although the striatum is thought to consist of sensorimotor, associative and limbic domains, their precise demarcations and whether additional functional subdivisions exist remain unclear. How striatal inputs are differentially segregated into each domain is also poorly understood. This study presents a comprehensive map of the excitatory inputs to the mouse striatum. The input patterns reveal boundaries between the known striatal domains. The most posterior striatum likely represents the 4th functional subdivision, and the dorsomedial striatum integrates highly heterogeneous, multimodal inputs. The complete thalamo-cortico-striatal loop is also presented, which reveals that the thalamic subregions innervated by the basal ganglia preferentially interconnect with motor-related cortical areas. Optogenetic experiments show the subregion-specific heterogeneity in the synaptic properties of striatal inputs from both the cortex and the thalamus. This projectome will guide functional studies investigating diverse striatal functions.
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.19103