Hydroxyzine Dihydrochloride Premedication Is a Necessity for Pediatric Patients Undergoing Strabismus Surgery: An Observational Prospective Clinical Trial

Objective. In this single-blind, observational prospective clinical trial, we aimed to determine and compare the effects of premedication with hydroxyzine plus midazolam and midazolam alone on the incidence of oculocardiac reflex (OCR). Methods. Forty-five patients were divided into three groups. Gr...

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Bibliographic Details
Published in:Journal of ophthalmology 2022-09, Vol.2022, p.1-7
Main Authors: Kartufan, Fatma Ferda, Kizilcik, Nurcan, Ziylan, Sule, Menda, Ferdi
Format: Article
Language:English
Subjects:
Anesthesia
Children
Clinical trials
Electrocardiography
Fruit juices
Health aspects
Heart beat
Heart rate
Hydroxyzine
Medical personnel
Patients
Pediatrics
Product development
Remifentanil
Strabismus
Surgeons
Surgery
Values
Vision disorders in children
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Summary:Objective. In this single-blind, observational prospective clinical trial, we aimed to determine and compare the effects of premedication with hydroxyzine plus midazolam and midazolam alone on the incidence of oculocardiac reflex (OCR). Methods. Forty-five patients were divided into three groups. Group M received 0.5 mg/kg midazolam alone, Group H received 0.5 mg/kg hydroxyzine plus 0.5 mg/kg midazolam, and Group HM received 1 mg/kg hydroxyzine plus 0.5 mg/kg midazolam. The Ramsay Sedation Scale (RSS), the heart rates (HR1: after induction of anesthesia; HR2: before retraction of orbital muscle; and HR3: right after retraction of orbital muscle), the muscles with OCR, and the incidence of OCR (20% decrease of the HR right after the traction) were recorded and compared between the three groups. Results. The mean HR1, HR2, and HR3 values were significantly increased (p=0.002, p
ISSN:2090-004X
2090-0058
DOI:10.1155/2022/4137144