Hydroxyzine Dihydrochloride Premedication Is a Necessity for Pediatric Patients Undergoing Strabismus Surgery: An Observational Prospective Clinical Trial

Objective. In this single-blind, observational prospective clinical trial, we aimed to determine and compare the effects of premedication with hydroxyzine plus midazolam and midazolam alone on the incidence of oculocardiac reflex (OCR). Methods. Forty-five patients were divided into three groups. Gr...

Full description

Saved in:
Bibliographic Details
Published in:Journal of ophthalmology 2022-09, Vol.2022, p.1-7
Main Authors: Kartufan, Fatma Ferda, Kizilcik, Nurcan, Ziylan, Sule, Menda, Ferdi
Format: Article
Language:English
Subjects:
Anesthesia
Children
Clinical trials
Electrocardiography
Fruit juices
Health aspects
Heart beat
Heart rate
Hydroxyzine
Medical personnel
Patients
Pediatrics
Product development
Remifentanil
Strabismus
Surgeons
Surgery
Values
Vision disorders in children
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c476t-ca7fa4f489dd0dd2f0c45b037ad7165096c3fe8ba9ee9b5f038a765e8a9526273
container_end_page 7
container_issue
container_start_page 1
container_title Journal of ophthalmology
container_volume 2022
creator Kartufan, Fatma Ferda
Kizilcik, Nurcan
Ziylan, Sule
Menda, Ferdi
description Objective. In this single-blind, observational prospective clinical trial, we aimed to determine and compare the effects of premedication with hydroxyzine plus midazolam and midazolam alone on the incidence of oculocardiac reflex (OCR). Methods. Forty-five patients were divided into three groups. Group M received 0.5 mg/kg midazolam alone, Group H received 0.5 mg/kg hydroxyzine plus 0.5 mg/kg midazolam, and Group HM received 1 mg/kg hydroxyzine plus 0.5 mg/kg midazolam. The Ramsay Sedation Scale (RSS), the heart rates (HR1: after induction of anesthesia; HR2: before retraction of orbital muscle; and HR3: right after retraction of orbital muscle), the muscles with OCR, and the incidence of OCR (20% decrease of the HR right after the traction) were recorded and compared between the three groups. Results. The mean HR1, HR2, and HR3 values were significantly increased (p=0.002, p
doi_str_mv 10.1155/2022/4137144
format article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_a4e84ab8fa8544d4bfec47395885a47e</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A720580237</galeid><doaj_id>oai_doaj_org_article_a4e84ab8fa8544d4bfec47395885a47e</doaj_id><sourcerecordid>A720580237</sourcerecordid><originalsourceid>FETCH-LOGICAL-c476t-ca7fa4f489dd0dd2f0c45b037ad7165096c3fe8ba9ee9b5f038a765e8a9526273</originalsourceid><addsrcrecordid>eNp9kl1v0zAUhiMEEtPYHT_AEhJCgm6OYzcJF0hV-ViliVXaJnFnndgniavULnZSKD-FX4uzVoMihH3hr8fvsd9zkuR5Ss_TVIgLRhm74GmWp5w_Sk4YLemEUlE8fpjzL0-TsxBWNLYs5ULQk-Tn5U579333w1gk7007rlTbOW80kqXHNWqjoDfOkkUgQD6jwhBMvyO182QZT6H3RpFlZND2gdxZjb5xxjbkpvdQmbAeArkZfIN-95bMLLmuAvrtvSZ0MYYLG1S92SKZd8bGaB259Qa6Z8mTGrqAZ4fxNLn7-OF2fjm5uv60mM-uJorn036iIK-B17wotaZas5oqLiqa5aDzdCpoOVVZjUUFJWJZiZpmBeRTgQWUgk1Znp0mi72udrCSG2_W4HfSgZH3G843EnxvVIcSOBYcqqKGQnCueVVjfERWiqIQwHOMWu_2WpuhitapaImH7kj0-MSaVjZuK0uRlhmjUeDVQcC7rwOGXq5NUNh1YNENQbI8JpPllJURffEXunKDj57uKcZZLIXfVAPxA8bWLsZVo6icRUoUlGWjB-f_oGLXuDbKWaxN3D-68PKPCy1C17fBdcOY1XAMvtmDKiY6eKwfzEipHAtXjoUrD4Ub8dd7vDVWwzfzf_oX3erucw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2720242714</pqid></control><display><type>article</type><title>Hydroxyzine Dihydrochloride Premedication Is a Necessity for Pediatric Patients Undergoing Strabismus Surgery: An Observational Prospective Clinical Trial</title><source>Publicly Available Content Database</source><source>Wiley Online Library (Open Access Collection)</source><source>PubMed Central</source><creator>Kartufan, Fatma Ferda ; Kizilcik, Nurcan ; Ziylan, Sule ; Menda, Ferdi</creator><contributor>Figus, Michele ; Michele Figus</contributor><creatorcontrib>Kartufan, Fatma Ferda ; Kizilcik, Nurcan ; Ziylan, Sule ; Menda, Ferdi ; Figus, Michele ; Michele Figus</creatorcontrib><description>Objective. In this single-blind, observational prospective clinical trial, we aimed to determine and compare the effects of premedication with hydroxyzine plus midazolam and midazolam alone on the incidence of oculocardiac reflex (OCR). Methods. Forty-five patients were divided into three groups. Group M received 0.5 mg/kg midazolam alone, Group H received 0.5 mg/kg hydroxyzine plus 0.5 mg/kg midazolam, and Group HM received 1 mg/kg hydroxyzine plus 0.5 mg/kg midazolam. The Ramsay Sedation Scale (RSS), the heart rates (HR1: after induction of anesthesia; HR2: before retraction of orbital muscle; and HR3: right after retraction of orbital muscle), the muscles with OCR, and the incidence of OCR (20% decrease of the HR right after the traction) were recorded and compared between the three groups. Results. The mean HR1, HR2, and HR3 values were significantly increased (p=0.002, p&lt;0.001, p&lt;0.001) and the incidence of OCR (p=0.004) was significantly decreased in Group H and in Group HM (for all, p&lt;0.01) compared to Group M. The most common orbital muscle in which OCR occurred was the rectus medialis. Conclusion. Premedication with a combination of 0.5 or 1 mg hydroxyzine with 0.5 mg midazolam significantly reduced the incidence of OCR compared to premedication with midazolam alone. This study was registered on https://clinicaltrials.gov/ with number NCT03806270.</description><identifier>ISSN: 2090-004X</identifier><identifier>EISSN: 2090-0058</identifier><identifier>DOI: 10.1155/2022/4137144</identifier><language>eng</language><publisher>New York: Hindawi</publisher><subject>Anesthesia ; Children ; Clinical trials ; Electrocardiography ; Fruit juices ; Health aspects ; Heart beat ; Heart rate ; Hydroxyzine ; Medical personnel ; Patients ; Pediatrics ; Product development ; Remifentanil ; Strabismus ; Surgeons ; Surgery ; Values ; Vision disorders in children</subject><ispartof>Journal of ophthalmology, 2022-09, Vol.2022, p.1-7</ispartof><rights>Copyright © 2022 Fatma Ferda Kartufan et al.</rights><rights>COPYRIGHT 2022 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2022 Fatma Ferda Kartufan et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2022 Fatma Ferda Kartufan et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c476t-ca7fa4f489dd0dd2f0c45b037ad7165096c3fe8ba9ee9b5f038a765e8a9526273</cites><orcidid>0000-0002-5592-2366</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2720242714/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2720242714?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids></links><search><contributor>Figus, Michele</contributor><contributor>Michele Figus</contributor><creatorcontrib>Kartufan, Fatma Ferda</creatorcontrib><creatorcontrib>Kizilcik, Nurcan</creatorcontrib><creatorcontrib>Ziylan, Sule</creatorcontrib><creatorcontrib>Menda, Ferdi</creatorcontrib><title>Hydroxyzine Dihydrochloride Premedication Is a Necessity for Pediatric Patients Undergoing Strabismus Surgery: An Observational Prospective Clinical Trial</title><title>Journal of ophthalmology</title><description>Objective. In this single-blind, observational prospective clinical trial, we aimed to determine and compare the effects of premedication with hydroxyzine plus midazolam and midazolam alone on the incidence of oculocardiac reflex (OCR). Methods. Forty-five patients were divided into three groups. Group M received 0.5 mg/kg midazolam alone, Group H received 0.5 mg/kg hydroxyzine plus 0.5 mg/kg midazolam, and Group HM received 1 mg/kg hydroxyzine plus 0.5 mg/kg midazolam. The Ramsay Sedation Scale (RSS), the heart rates (HR1: after induction of anesthesia; HR2: before retraction of orbital muscle; and HR3: right after retraction of orbital muscle), the muscles with OCR, and the incidence of OCR (20% decrease of the HR right after the traction) were recorded and compared between the three groups. Results. The mean HR1, HR2, and HR3 values were significantly increased (p=0.002, p&lt;0.001, p&lt;0.001) and the incidence of OCR (p=0.004) was significantly decreased in Group H and in Group HM (for all, p&lt;0.01) compared to Group M. The most common orbital muscle in which OCR occurred was the rectus medialis. Conclusion. Premedication with a combination of 0.5 or 1 mg hydroxyzine with 0.5 mg midazolam significantly reduced the incidence of OCR compared to premedication with midazolam alone. This study was registered on https://clinicaltrials.gov/ with number NCT03806270.</description><subject>Anesthesia</subject><subject>Children</subject><subject>Clinical trials</subject><subject>Electrocardiography</subject><subject>Fruit juices</subject><subject>Health aspects</subject><subject>Heart beat</subject><subject>Heart rate</subject><subject>Hydroxyzine</subject><subject>Medical personnel</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Product development</subject><subject>Remifentanil</subject><subject>Strabismus</subject><subject>Surgeons</subject><subject>Surgery</subject><subject>Values</subject><subject>Vision disorders in children</subject><issn>2090-004X</issn><issn>2090-0058</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9kl1v0zAUhiMEEtPYHT_AEhJCgm6OYzcJF0hV-ViliVXaJnFnndgniavULnZSKD-FX4uzVoMihH3hr8fvsd9zkuR5Ss_TVIgLRhm74GmWp5w_Sk4YLemEUlE8fpjzL0-TsxBWNLYs5ULQk-Tn5U579333w1gk7007rlTbOW80kqXHNWqjoDfOkkUgQD6jwhBMvyO182QZT6H3RpFlZND2gdxZjb5xxjbkpvdQmbAeArkZfIN-95bMLLmuAvrtvSZ0MYYLG1S92SKZd8bGaB259Qa6Z8mTGrqAZ4fxNLn7-OF2fjm5uv60mM-uJorn036iIK-B17wotaZas5oqLiqa5aDzdCpoOVVZjUUFJWJZiZpmBeRTgQWUgk1Znp0mi72udrCSG2_W4HfSgZH3G843EnxvVIcSOBYcqqKGQnCueVVjfERWiqIQwHOMWu_2WpuhitapaImH7kj0-MSaVjZuK0uRlhmjUeDVQcC7rwOGXq5NUNh1YNENQbI8JpPllJURffEXunKDj57uKcZZLIXfVAPxA8bWLsZVo6icRUoUlGWjB-f_oGLXuDbKWaxN3D-68PKPCy1C17fBdcOY1XAMvtmDKiY6eKwfzEipHAtXjoUrD4Ub8dd7vDVWwzfzf_oX3erucw</recordid><startdate>20220921</startdate><enddate>20220921</enddate><creator>Kartufan, Fatma Ferda</creator><creator>Kizilcik, Nurcan</creator><creator>Ziylan, Sule</creator><creator>Menda, Ferdi</creator><general>Hindawi</general><general>John Wiley &amp; Sons, Inc</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-5592-2366</orcidid></search><sort><creationdate>20220921</creationdate><title>Hydroxyzine Dihydrochloride Premedication Is a Necessity for Pediatric Patients Undergoing Strabismus Surgery: An Observational Prospective Clinical Trial</title><author>Kartufan, Fatma Ferda ; Kizilcik, Nurcan ; Ziylan, Sule ; Menda, Ferdi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-ca7fa4f489dd0dd2f0c45b037ad7165096c3fe8ba9ee9b5f038a765e8a9526273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anesthesia</topic><topic>Children</topic><topic>Clinical trials</topic><topic>Electrocardiography</topic><topic>Fruit juices</topic><topic>Health aspects</topic><topic>Heart beat</topic><topic>Heart rate</topic><topic>Hydroxyzine</topic><topic>Medical personnel</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Product development</topic><topic>Remifentanil</topic><topic>Strabismus</topic><topic>Surgeons</topic><topic>Surgery</topic><topic>Values</topic><topic>Vision disorders in children</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kartufan, Fatma Ferda</creatorcontrib><creatorcontrib>Kizilcik, Nurcan</creatorcontrib><creatorcontrib>Ziylan, Sule</creatorcontrib><creatorcontrib>Menda, Ferdi</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kartufan, Fatma Ferda</au><au>Kizilcik, Nurcan</au><au>Ziylan, Sule</au><au>Menda, Ferdi</au><au>Figus, Michele</au><au>Michele Figus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hydroxyzine Dihydrochloride Premedication Is a Necessity for Pediatric Patients Undergoing Strabismus Surgery: An Observational Prospective Clinical Trial</atitle><jtitle>Journal of ophthalmology</jtitle><date>2022-09-21</date><risdate>2022</risdate><volume>2022</volume><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>2090-004X</issn><eissn>2090-0058</eissn><abstract>Objective. In this single-blind, observational prospective clinical trial, we aimed to determine and compare the effects of premedication with hydroxyzine plus midazolam and midazolam alone on the incidence of oculocardiac reflex (OCR). Methods. Forty-five patients were divided into three groups. Group M received 0.5 mg/kg midazolam alone, Group H received 0.5 mg/kg hydroxyzine plus 0.5 mg/kg midazolam, and Group HM received 1 mg/kg hydroxyzine plus 0.5 mg/kg midazolam. The Ramsay Sedation Scale (RSS), the heart rates (HR1: after induction of anesthesia; HR2: before retraction of orbital muscle; and HR3: right after retraction of orbital muscle), the muscles with OCR, and the incidence of OCR (20% decrease of the HR right after the traction) were recorded and compared between the three groups. Results. The mean HR1, HR2, and HR3 values were significantly increased (p=0.002, p&lt;0.001, p&lt;0.001) and the incidence of OCR (p=0.004) was significantly decreased in Group H and in Group HM (for all, p&lt;0.01) compared to Group M. The most common orbital muscle in which OCR occurred was the rectus medialis. Conclusion. Premedication with a combination of 0.5 or 1 mg hydroxyzine with 0.5 mg midazolam significantly reduced the incidence of OCR compared to premedication with midazolam alone. This study was registered on https://clinicaltrials.gov/ with number NCT03806270.</abstract><cop>New York</cop><pub>Hindawi</pub><doi>10.1155/2022/4137144</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-5592-2366</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2090-004X
ispartof Journal of ophthalmology, 2022-09, Vol.2022, p.1-7
issn 2090-004X
2090-0058
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_a4e84ab8fa8544d4bfec47395885a47e
source Publicly Available Content Database; Wiley Online Library (Open Access Collection); PubMed Central
subjects Anesthesia
Children
Clinical trials
Electrocardiography
Fruit juices
Health aspects
Heart beat
Heart rate
Hydroxyzine
Medical personnel
Patients
Pediatrics
Product development
Remifentanil
Strabismus
Surgeons
Surgery
Values
Vision disorders in children
title Hydroxyzine Dihydrochloride Premedication Is a Necessity for Pediatric Patients Undergoing Strabismus Surgery: An Observational Prospective Clinical Trial
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T10%3A52%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hydroxyzine%20Dihydrochloride%20Premedication%20Is%20a%20Necessity%20for%20Pediatric%20Patients%20Undergoing%20Strabismus%20Surgery:%20An%20Observational%20Prospective%20Clinical%20Trial&rft.jtitle=Journal%20of%20ophthalmology&rft.au=Kartufan,%20Fatma%20Ferda&rft.date=2022-09-21&rft.volume=2022&rft.spage=1&rft.epage=7&rft.pages=1-7&rft.issn=2090-004X&rft.eissn=2090-0058&rft_id=info:doi/10.1155/2022/4137144&rft_dat=%3Cgale_doaj_%3EA720580237%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c476t-ca7fa4f489dd0dd2f0c45b037ad7165096c3fe8ba9ee9b5f038a765e8a9526273%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2720242714&rft_id=info:pmid/&rft_galeid=A720580237&rfr_iscdi=true