Cryostructuring of Polymeric Systems: 64. Preparation and Properties of Poly(vinyl alcohol)-Based Cryogels Loaded with Antimicrobial Drugs and Assessment of the Potential of Such Gel Materials to Perform as Gel Implants for the Treatment of Infected Wounds

Physical macroporous poly(vinyl alcohol)-based cryogels formed by the freeze-thaw technique without the use of any foreign cross-linkers are of significant interests for biomedical applications. In the present study, such gel materials loaded with the antimicrobial substances were prepared and their...

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Bibliographic Details
Published in:Gels 2023-01, Vol.9 (2), p.113
Main Authors: Kolosova, Olga Yu, Shaikhaliev, Astemir I, Krasnov, Mikhail S, Bondar, Ivan M, Sidorskii, Egor V, Sorokina, Elena V, Lozinsky, Vladimir I
Format: Article
Language:English
Subjects:
Additives
Analysis
Antibiotics
Antiinfectives and antibacterials
antimicrobial implants
Biomedical engineering
Biomedical materials
Ceftriaxone
Ceftriaxone sodium
Diffusion
Drug carriers
Drug delivery systems
drug release
Drug therapy
Drugs
Experiments
Fluconazole
Freeze-thaw
Heat
Hydrogels
in vitro and in vivo bioassay
In vivo methods and tests
Morphology
Oxytetracycline
poly(vinyl alcohol) cryogel
Polyvinyl alcohol
Rabbits
Reagents
Spectrophotometry
Surgery
Surgical implants
Transplants & implants
Vehicles
Wounds and injuries
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Summary:Physical macroporous poly(vinyl alcohol)-based cryogels formed by the freeze-thaw technique without the use of any foreign cross-linkers are of significant interests for biomedical applications. In the present study, such gel materials loaded with the antimicrobial substances were prepared and their physicochemical properties were evaluated followed by an assessment of their potential to serve as drug carriers that can be used as implants for the treatment of infected wounds. The antibiotic Ceftriaxone and the antimycotic Fluconazole were used as antimicrobial agents. It was shown that the Ceftriaxone additives caused the up-swelling effects with respect to the cryogel matrix and some decrease in its heat endurance but did not result in a substantial change in the gel strength. With that, the drug release from the cryogel vehicle occurred without any diffusion restrictions, which was demonstrated by both the spectrophotometric recording and the microbiological agar diffusion technique. In turn, the in vivo biotesting of such drug-loaded cryogels also showed that these materials were able to function as rather efficient antimicrobial implants injected in the artificially infected model wounds of laboratory rabbits. These results confirmed the promising biomedical potential of similar implants.
ISSN:2310-2861
2310-2861
DOI:10.3390/gels9020113