1-Tetradecanol, Diethyl Phthalate and Tween 80 Assist in the Formation of Thermo-Responsive Azoxystrobin Nanoparticles

• Published in: Molecules (Basel, Switzerland) Switzerland), 2022-11, Vol.27 (22), p.7959
• Main Authors: Lin, Guan, Gao, Juntao, Shang, Shenghua, Zhang, Huanbo, Luo, Qiangke, Wu, Yutong, Liu, Yong, Chen, Xingjiang, Sun, Yan
• Format: Article
• Language: English
• Subjects: 1-tetradecanol; Agrochemicals; Antifungal activity; Antifungal agents; Antifungal Agents - pharmacology; Azoxystrobin; Bioavailability; Crystallization; efficacy; Environmental conditions; Fungal diseases; Fungi; Fungicides; Fungicides, Industrial - pharmacology; Genetic transformation; Nanoemulsions; nanoparticle; Nanoparticles; Nanoparticles - chemistry; Pesticides; Polysorbates - chemistry; Reforming; Spores; Surface active agents; Technical services; thermo-responsive; Zeta potential
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27227959

The occurrence of crop fungal diseases is closely related to warm environmental conditions. In order to control the release of fungicides in response to warm conditions, and enhance the efficacy, a series of thermo-responsive fungicide-loaded nanoparticles were developed. The fungicide azoxystrobin, solvent DEP, emulsifier Tween 80 and thermo-responsive component TDA were combined to create thermal-response oil phases, conditions for emulsification were then optimized. LDLS, zeta potential, FTIR, DSC, TGA, XRD, SEM and antifungal efficacy assays were carried out to investigate the characteristics and forming mechanism. The results indicated that the formula with 5 g azoxystrobin, 10 mL DEP, 6 mL Tween 80 and 2.5 g TDA constructed the proposed oil phase with the ability to transform from solid at 20 °C to softerned at 31.5 °C. Both DEP and TDA played key roles in interfering with the crystallization of azoxystrobin. The optimal T3t-c12 nanoparticles had a mean particle size of 162.1 nm, thermo-responsive morphological transformation between 20 °C and 30 °C, AZO crystal reforming after drying, the ability to attach to fungal spores and satisfied antifungal efficacy against PNgz07 and A1513 at 30 °C. This report provides referable technical support for the construction of smart-release nanoparticles of other agrochemicals.