Notch Signaling Pathway in Tooth Shape Variations throughout Evolution

Evolutionary changes in vertebrates are linked to genetic alterations that often affect tooth crown shape, which is a criterion of speciation events. The Notch pathway is highly conserved between species and controls morphogenetic processes in most developing organs, including teeth. Epithelial loss...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2023-02, Vol.12 (5), p.761
Main Authors: Mitsiadis, Thimios A, Pagella, Pierfrancesco, Gomes Rodrigues, Helder, Tsouknidas, Alexander, Ramenzoni, Liza L, Radtke, Freddy, Mehl, Albert, Viriot, Laurent
Format: Article
Language:English
Subjects:
Animals
Cell receptors
Cellular signal transduction
Evolution
Fibroblast Growth Factors - metabolism
Genetic aspects
Growth factors
Health aspects
human
Humans
Investigations
Jagged-1 Protein
Jagged1
Jagged1 protein
Life Sciences
Metamorphosis
Mice
Molars
Morphogenesis
Morphology
mouse
Mutation
Natural history
notch signaling
Odontogenesis
Pathogens
Physiological aspects
RNA analysis
Sequence analysis
Signal Transduction
Speciation
Teeth
tooth
Tooth - metabolism
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Summary:Evolutionary changes in vertebrates are linked to genetic alterations that often affect tooth crown shape, which is a criterion of speciation events. The Notch pathway is highly conserved between species and controls morphogenetic processes in most developing organs, including teeth. Epithelial loss of the Notch-ligand Jagged1 in developing mouse molars affects the location, size and interconnections of their cusps that lead to minor tooth crown shape modifications convergent to those observed along Muridae evolution. RNA sequencing analysis revealed that these alterations are due to the modulation of more than 2000 genes and that Notch signaling is a hub for significant morphogenetic networks, such as Wnts and Fibroblast Growth Factors. The modeling of these tooth crown changes in mutant mice, via a three-dimensional metamorphosis approach, allowed prediction of how Jagged1-associated mutations in humans could affect the morphology of their teeth. These results shed new light on Notch/Jagged1-mediated signaling as one of the crucial components for dental variations in evolution.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells12050761