Editing out HIV: application of gene editing technology to achieve functional cure

Highly active antiretroviral therapy (HAART) successfully suppresses human immunodeficiency virus (HIV) replication and improves the quality of life of patients living with HIV. However, current HAART does not eradicate HIV infection because an HIV reservoir is established in latently infected cells...

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Bibliographic Details
Published in:Retrovirology 2021-12, Vol.18 (1), p.39-39, Article 39
Main Authors: Xun, Jingna, Zhang, Xinyu, Guo, Shuyan, Lu, Hongzhou, Chen, Jun
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
Antiretroviral drugs
Antiretroviral Therapy, Highly Active
Bone marrow
Bone marrow transplantation
Clinical trials
Control
DNA methylation
Enzymes
Functional cure
Gene Editing
Genes
Genetic research
Genome editing
Genomes
Health aspects
Highly active antiretroviral therapy
HIV
HIV (Viruses)
HIV infection
HIV Infections - drug therapy
HIV/AIDS
Human immunodeficiency virus
Humans
Immune system
Infection
Infections
Latent infection
Leukemia
Lymphocytes
Lymphoma
Medical research
Medicine, Experimental
Mutation
Patients
Proteins
Quality of Life
Review
Technology
Transplantation
Transplants & implants
Virus Latency
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Summary:Highly active antiretroviral therapy (HAART) successfully suppresses human immunodeficiency virus (HIV) replication and improves the quality of life of patients living with HIV. However, current HAART does not eradicate HIV infection because an HIV reservoir is established in latently infected cells and is not recognized by the immune system. The successful curative treatment of the Berlin and London patients following bone marrow transplantation inspired researchers to identify an approach for the functional cure of HIV. As a promising technology, gene editing-based strategies have attracted considerable attention and sparked much debate. Herein, we discuss the development of different gene editing strategies in the functional cure of HIV and highlight the potential for clinical applications prospects.
ISSN:1742-4690
1742-4690
DOI:10.1186/s12977-021-00581-1