Development of Plant Protein Derived Tri Angular Shaped Nano Zinc Oxide Particles with Inherent Antibacterial and Neurotoxicity Properties

The synthesis of nanometer-sized metallic nanoparticles utilizing bio-sources is one of the most cost-effective and ecologically friendly approaches. Nano-zinc oxide particles (N-ZnO Ps) were made using a simple green synthesis method using an aqueous zinc nitrate salt and Perilla frutescens crude p...

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Published in:Pharmaceutics 2022-10, Vol.14 (10), p.2155
Main Authors: Hou, Tianyu, Sankar Sana, Siva, Li, Huizhen, Wang, Xin, Wang, Qinqin, Boya, Vijaya Kumar Naidu, Vadde, Ramakrishna, Kumar, Raj, Kumbhakar, Divya Vishambhar, Zhang, Zhijun, Mamidi, Narsimha
Format: Article
Language:English
Subjects:
Amino acids
antibacterial activity
anticancer activity
Antimicrobial agents
biosynthesis
Chemical properties
Collaboration
Cytotoxicity
Enzymes
Health aspects
HR-TEM
Metal oxides
N-ZnO Ps
Nanoparticles
Nanotechnology
Phytochemicals
Plant proteins
Proteins
Seeds
Spectrum analysis
Structure
Zinc oxides
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Summary:The synthesis of nanometer-sized metallic nanoparticles utilizing bio-sources is one of the most cost-effective and ecologically friendly approaches. Nano-zinc oxide particles (N-ZnO Ps) were made using a simple green synthesis method using an aqueous zinc nitrate salt and Perilla frutescens crude protein as a protecting and reducing agent in the current work. UV-visible (UV-vis) spectrophotometry, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), (energy dispersive x-ray spectroscopy) EDX and high-resolution transmission electron microscopy (HR-TEM) were used to characterize the synthesized N-ZnO Ps. A distinctive UV-vis absorption peak was observed at 370 nm due to N-ZnO Ps. The SEM and HR-TEM pictures revealed N-ZnO Ps with a triangular form. The XRD pattern indicated the wurtzite structure of N-ZnO Ps. Nanoparticles exhibited a zeta potential of −11.3 mV. The antibacterial activity of N-ZnO Ps was tested against Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumonia) microorganisms. The N-ZnO Ps were non-toxic to HMC-3 human normal brain microglia cells; however, they exhibited a potential cytotoxic effect on the LN-18 human brain glioblastoma cell line. These results indicate that N-ZnOPs can act as promising antibacterial and anticancer treatments in the prevention of Glioblastoma.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14102155