Blood pressure and outcome after aneurysmal subarachnoid hemorrhage

Blood pressure management is crucial in the treatment of patients with aneurysmal subarachnoid hemorrhage (aSAH). Possible association between the blood pressure increase and the risk of delayed cerebral ischemia (DCI) and different systemic complications after aSAH is still a matter of debate. This...

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Bibliographic Details
Published in:Scientific reports 2022-05, Vol.12 (1), p.8006-8006, Article 8006
Main Authors: Darkwah Oppong, Marvin, Steinwasser, Lisa, Rieß, Christoph, Wrede, Karsten H., Dinger, Thiemo F., Ahmadipour, Yahya, Dammann, Philipp, Rauschenbach, Laurèl, Gümüs, Meltem, Deuschl, Cornelius, Sure, Ulrich, Jabbarli, Ramazan
Format: Article
Language:English
Subjects:
692/617/375/1370
692/617/375/1370/534
Aneurysm
Blood pressure
Computed tomography
DRKS
DRKS00008749
Heart
Humanities and Social Sciences
Hypertension
Ischemia
multidisciplinary
Nephrology
Patients
Regression analysis
Science
Science (multidisciplinary)
Stroke
Subarachnoid hemorrhage
Therapeutic targets
Vasoconstriction
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Summary:Blood pressure management is crucial in the treatment of patients with aneurysmal subarachnoid hemorrhage (aSAH). Possible association between the blood pressure increase and the risk of delayed cerebral ischemia (DCI) and different systemic complications after aSAH is still a matter of debate. This study aims to elucidate the influence of blood pressure levels on the outcome of aSAH. All consecutive aSAH patients (n = 690) treated between 01/2003 and 06/2016 were included. The mean value of the mean arterial pressure (MAP) during 14 days after ictus was calculated for each individual. According to the institutional standards of vasospasm management, the mean 14 days MAP ≥ 95 mmHg was referred as increased (IMAP) and the patients with and without vasospasm were analyzed separately. Study endpoints were the occurrence of DCI on computed tomography scans, development of cardiac and nephrological complications, and poor outcome 6 months after aSAH (mRS > 2). Associations were tested in univariable/multivariable binary logistic regression analysis. IMAP was documented in 474 (68.7%) cases and was more common in individuals with poor neurological conditions at admission (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-11903-4