The association of serum uric acid/albumin ratio with the development of coronary collateral circulation in patients with chronic total occluded coronary arteries

Coronary collateral circulation (CCC) develops in chronic total occluded (CTO) vessels and protects the myocardium against ischemia in addition to the improvement of cardiac functions. Poor CCC is related to adverse cardiac events as well as poor prognosis. Serum uric acid/albumin ratio (UAR) has em...

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Bibliographic Details
Published in:Journal of cardiovascular and thoracic research 2023-01, Vol.15 (1), p.14-21
Main Authors: Şaylık, Faysal, Çınar, Tufan, Sarıkaya, Remzi, Akbulut, Tayyar, Selçuk, Murat, Özbek, Emrah, Tanboğa, Halil İbrahim
Format: Article
Language:English
Subjects:
Blood pressure
Cardiology
Cardiovascular disease
chronic total occlusion
coronary collateral circulation
Coronary vessels
Diabetes
Ejection fraction
Electrocardiography
Heart failure
Ischemia
Original
Regression analysis
rentrop score
Uric acid
uric acid/ albumin ratio
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Summary:Coronary collateral circulation (CCC) develops in chronic total occluded (CTO) vessels and protects the myocardium against ischemia in addition to the improvement of cardiac functions. Poor CCC is related to adverse cardiac events as well as poor prognosis. Serum uric acid/albumin ratio (UAR) has emerged as a novel marker associated with poor cardiovascular outcomes. We aimed to investigate whether there was an association between UAR and poor CCC in CTO patients. This study was comprised of 212 patients with CTO (92 with poor CCC and 120 with good CCC). All patients were graded based on Rentrop scores to poor CCC (Rentrop scores 0 and 1) and good CCC (Rentrop scores 2 and 3). Poor CCC patients had higher frequencies of diabetes mellitus, triglyceride levels, Syntax and Gensini scores, uric acid, and UAR and lower lymphocyte, high-density lipoprotein cholesterol, and ejection fraction when compared to good CCC patients. UAR was an independent predictor of poor CCC in CTO patients. Furthermore, UAR had a better discriminative ability for patients with poor CCC from good CCC compared to serum uric acid and albumin. Based on the results of the study, the UAR could be used to detect poor CCC in CTO patients.
ISSN:2008-5117
2008-6830
DOI:10.34172/jcvtr.2023.31627