Labor epidural analgesia and risk of autism Spectrum disorders in offspring: A systematic review and meta-analysis

The effect of labor epidural anesthesia (LEA) on the risk of autism spectrum disorder (ASD) in offspring has been investigated recently, and available results are inconsistent. We searched the PubMed and EMBASE databases for relevant studies and performed a systematic review and meta-analysis of the...

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Bibliographic Details
Published in:Frontiers in pediatrics 2023-02, Vol.10, p.965205-965205
Main Authors: Fang, Ling-Ling, Zhou, Yuan-Yue, Jiang, Hai-Yin, Shi, Yu-Dan
Format: Article
Language:English
Subjects:
analgesia
children
meta-analysis
neurodevelopment
pain
Pediatrics
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Summary:The effect of labor epidural anesthesia (LEA) on the risk of autism spectrum disorder (ASD) in offspring has been investigated recently, and available results are inconsistent. We searched the PubMed and EMBASE databases for relevant studies and performed a systematic review and meta-analysis of the literature. Subgroup analyses were conducted to assess the sources of heterogeneity. Both fixed and random effects models were used was used to estimate overall relative risk. Our results showed that LEA was associated with an increased risk of ASD in offspring [HR = 1.3, 95% confidence interval (CI): 1.25-1.35;  
ISSN:2296-2360
2296-2360
DOI:10.3389/fped.2022.965205