Bio-Inspired Nanocarriers Derived from Stem Cells and Their Extracellular Vesicles for Targeted Drug Delivery

With their seemingly limitless capacity for self-improvement, stem cells have a wide range of potential uses in the medical field. Stem-cell-secreted extracellular vesicles (EVs), as paracrine components of stem cells, are natural nanoscale particles that transport a variety of biological molecules...

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Bibliographic Details
Published in:Pharmaceutics 2023-07, Vol.15 (7), p.2011
Main Authors: Abudurexiti, Munire, Zhao, Yue, Wang, Xiaoling, Han, Lu, Liu, Tianqing, Wang, Chengwei, Yuan, Zhixiang
Format: Article
Language:English
Subjects:
Alzheimer's disease
bio-inspired
Biocompatibility
Biomimetics
Blood
Cell division
Drug delivery systems
Drugs
Efficiency
Extracellular vesicles
Health aspects
Inflammation
Ligands
Membranes
nanocarriers
Nanoparticles
Nanotechnology
Protective coatings
Proteins
Review
Skin
stem cell
Stem cell research
Stem cells
targeted drug delivery
Vehicles
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Summary:With their seemingly limitless capacity for self-improvement, stem cells have a wide range of potential uses in the medical field. Stem-cell-secreted extracellular vesicles (EVs), as paracrine components of stem cells, are natural nanoscale particles that transport a variety of biological molecules and facilitate cell-to-cell communication which have been also widely used for targeted drug delivery. These nanocarriers exhibit inherent advantages, such as strong cell or tissue targeting and low immunogenicity, which synthetic nanocarriers lack. However, despite the tremendous therapeutic potential of stem cells and EVs, their further clinical application is still limited by low yield and a lack of standardized isolation and purification protocols. In recent years, inspired by the concept of biomimetics, a new approach to biomimetic nanocarriers for drug delivery has been developed through combining nanotechnology and bioengineering. This article reviews the application of biomimetic nanocarriers derived from stem cells and their EVs in targeted drug delivery and discusses their advantages and challenges in order to stimulate future research.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics15072011