Characterization of Fibrous Wollastonite NYAD G in View of Its Use as Negative Standard for In Vitro Toxicity Tests

Today, despite considerable efforts undertaken by the scientific community, the mechanisms of carcinogenesis of mineral fibres remain poorly understood. A crucial role in disclosing the mechanisms of action of mineral fibres is played by in vitro and in vivo models. Such models require experimental...

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Bibliographic Details
Published in:Minerals (Basel) 2021-12, Vol.11 (12), p.1378
Main Authors: Di Giuseppe, Dario, Scognamiglio, Valentina, Malferrari, Daniele, Nodari, Luca, Pasquali, Luca, Lassinantti Gualtieri, Magdalena, Scarfì, Sonia, Mirata, Serena, Tessari, Umberto, Hanuskova, Miriam, Gualtieri, Alessandro F.
Format: Article
Language:English
Subjects:
Amosite
Asbestos
Bioassays
Biocompatibility
Biomedical materials
Carcinogenesis
Carcinogens
Crocidolite
Design of experiments
Experimental design
Fibers
fibrous wollastonite
FPTI
Genotoxicity
In vitro methods and tests
In vivo methods and tests
Inflammation
Mesothelioma
Metals
Mineral fibers
mineral fibres
negative control
Oxidative stress
Pathogenicity
Pathogens
Tests
Toxicity
Toxicity testing
Toxicity tests
Wollastonite
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Summary:Today, despite considerable efforts undertaken by the scientific community, the mechanisms of carcinogenesis of mineral fibres remain poorly understood. A crucial role in disclosing the mechanisms of action of mineral fibres is played by in vitro and in vivo models. Such models require experimental design based on negative and positive controls. Commonly used positive controls are amosite and crocidolite UICC standards, while negative controls have not been identified so far. The extensive characterisation and assessment of toxicity/pathogenicity potential carried out in this work indicate that the commercial fibrous wollastonite NYAD G may be considered as a negative standard control for biological and biomedical tests involving mineral fibres. Preliminary in vitro tests suggest that wollastonite NYAD G is not genotoxic. This material is nearly pure and is characterized by very long (46.6 µm), thick (3.74 µm) and non-biodurable fibres with a low content of metals. According to the fibre potential toxicity index (FPTI) model, wollastonite NYAD G is an inert mineral fibre that is expected to exert a low biological response during in vitro/in vivo testing.
ISSN:2075-163X
2075-163X
DOI:10.3390/min11121378