Frequency-dependent effects of 0.05% atropine eyedrops on myopia progression and peripheral defocus: a prospective study

• Published in: Eye and vision (Novato, Calif.) Calif.), 2024-08, Vol.11 (1), p.26-11, Article 26
• Main Authors: Yang, Yuanfang, Xue, Minsong, Hao, Jiangdong, Lin, Zhenghua, Xi, Xiaoyun, Wu, Haoran, Wen, Longbo, Xu, Qinglin, Luo, Zhiwei, Ran, Guangyao, Artal, Pablo, Lan, Weizhong, Li, Xiaoning, Yang, Zhikuan
• Format: Article
• Language: English
• Subjects: 0.05% atropine eyedrops; Analysis; Atropine; Development and progression; Dosage and administration; Drug therapy; Health aspects; Medication compliance; Myopia; Myopia control; Ophthalmic solutions; Patient outcomes; Peripheral defocus; Pirenzepine; Sensors
• ISSN: 2326-0254; 2326-0254
• DOI: 10.1186/s40662-024-00395-0

Atropine, specifically 0.05% eyedrops, has proven effective in slowing myopia progression. This study aims to investigate peripheral refraction (PR) characteristics in myopic children treated with 0.05% atropine eyedrops at different frequencies. One hundred thirty-eight myopic children completed this one-year prospective study, randomly assigned to once daily (7/7), twice per week (2/7), or once per week (1/7) groups. Spherical equivalent (SE) and axial length (AL) were measured. PR was assessed using a custom-made Hartmann-Shack wavefront peripheral sensor, covering a visual field of horizontal 60° and vertical 36°. Relative peripheral refraction (RPR) was calculated by subtracting central from peripheral measurements. After one year, SE increased more significantly in the 1/7 group compared to the 7/7 group (P