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Frequency-dependent effects of 0.05% atropine eyedrops on myopia progression and peripheral defocus: a prospective study
Atropine, specifically 0.05% eyedrops, has proven effective in slowing myopia progression. This study aims to investigate peripheral refraction (PR) characteristics in myopic children treated with 0.05% atropine eyedrops at different frequencies. One hundred thirty-eight myopic children completed th...
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| Published in: | Eye and vision (Novato, Calif.) Calif.), 2024-08, Vol.11 (1), p.26-11, Article 26 |
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| container_title | Eye and vision (Novato, Calif.) |
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| creator | Yang, Yuanfang Xue, Minsong Hao, Jiangdong Lin, Zhenghua Xi, Xiaoyun Wu, Haoran Wen, Longbo Xu, Qinglin Luo, Zhiwei Ran, Guangyao Artal, Pablo Lan, Weizhong Li, Xiaoning Yang, Zhikuan |
| description | Atropine, specifically 0.05% eyedrops, has proven effective in slowing myopia progression. This study aims to investigate peripheral refraction (PR) characteristics in myopic children treated with 0.05% atropine eyedrops at different frequencies.
One hundred thirty-eight myopic children completed this one-year prospective study, randomly assigned to once daily (7/7), twice per week (2/7), or once per week (1/7) groups. Spherical equivalent (SE) and axial length (AL) were measured. PR was assessed using a custom-made Hartmann-Shack wavefront peripheral sensor, covering a visual field of horizontal 60° and vertical 36°. Relative peripheral refraction (RPR) was calculated by subtracting central from peripheral measurements.
After one year, SE increased more significantly in the 1/7 group compared to the 7/7 group (P |
| doi_str_mv | 10.1186/s40662-024-00395-0 |
| format | article |
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One hundred thirty-eight myopic children completed this one-year prospective study, randomly assigned to once daily (7/7), twice per week (2/7), or once per week (1/7) groups. Spherical equivalent (SE) and axial length (AL) were measured. PR was assessed using a custom-made Hartmann-Shack wavefront peripheral sensor, covering a visual field of horizontal 60° and vertical 36°. Relative peripheral refraction (RPR) was calculated by subtracting central from peripheral measurements.
After one year, SE increased more significantly in the 1/7 group compared to the 7/7 group (P < 0.001) and 2/7 group (P = 0.004); AL elongation was also greater in the 1/7 group compared to the 7/7 group (P < 0.001). In comparison with higher frequency groups, 1/7 group exhibited more myopic PR in the fovea and its vertical superior, inferior, and nasal retina; and less myopic RPR in the periphery retina after one-year (P < 0.05). Additionally, RPR in the 7/7 group demonstrated myopic shift across the entire retina, the 2/7 group in temporal and inferior retina, while the 1/7 group showed a hyperopic shift in the superior retina (P < 0.05). Moreover, myopic shift of RPR in the temporal retina is related to less myopia progression, notably in the 7/7 group (P < 0.05).
Atropine inhibits myopia progression in a frequency-dependent manner. The once-daily group showed the slowest myopia progression but exhibited more myopic shifts in RPR. Additionally, RPR in the temporal retina was related to myopia progression in all groups.
Chinese Clinical Trial Registry, ChiCTR2100043506. Registered 21 February 2021, https://www.chictr.org.cn/showproj.html?proj=122214.</description><identifier>ISSN: 2326-0254</identifier><identifier>EISSN: 2326-0254</identifier><identifier>DOI: 10.1186/s40662-024-00395-0</identifier><identifier>PMID: 39085950</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>0.05% atropine eyedrops ; Analysis ; Atropine ; Development and progression ; Dosage and administration ; Drug therapy ; Health aspects ; Medication compliance ; Myopia ; Myopia control ; Ophthalmic solutions ; Patient outcomes ; Peripheral defocus ; Pirenzepine ; Sensors</subject><ispartof>Eye and vision (Novato, Calif.), 2024-08, Vol.11 (1), p.26-11, Article 26</ispartof><rights>2024. The Author(s).</rights><rights>COPYRIGHT 2024 BioMed Central Ltd.</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c448t-f2bc45e7364dff3e0483f1f78344825f6dd5bfea363a00dc215cade8bbd4492d3</cites><orcidid>0000-0003-4921-6825</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11293060/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11293060/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,36994,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39085950$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Yuanfang</creatorcontrib><creatorcontrib>Xue, Minsong</creatorcontrib><creatorcontrib>Hao, Jiangdong</creatorcontrib><creatorcontrib>Lin, Zhenghua</creatorcontrib><creatorcontrib>Xi, Xiaoyun</creatorcontrib><creatorcontrib>Wu, Haoran</creatorcontrib><creatorcontrib>Wen, Longbo</creatorcontrib><creatorcontrib>Xu, Qinglin</creatorcontrib><creatorcontrib>Luo, Zhiwei</creatorcontrib><creatorcontrib>Ran, Guangyao</creatorcontrib><creatorcontrib>Artal, Pablo</creatorcontrib><creatorcontrib>Lan, Weizhong</creatorcontrib><creatorcontrib>Li, Xiaoning</creatorcontrib><creatorcontrib>Yang, Zhikuan</creatorcontrib><title>Frequency-dependent effects of 0.05% atropine eyedrops on myopia progression and peripheral defocus: a prospective study</title><title>Eye and vision (Novato, Calif.)</title><addtitle>Eye Vis (Lond)</addtitle><description>Atropine, specifically 0.05% eyedrops, has proven effective in slowing myopia progression. This study aims to investigate peripheral refraction (PR) characteristics in myopic children treated with 0.05% atropine eyedrops at different frequencies.
One hundred thirty-eight myopic children completed this one-year prospective study, randomly assigned to once daily (7/7), twice per week (2/7), or once per week (1/7) groups. Spherical equivalent (SE) and axial length (AL) were measured. PR was assessed using a custom-made Hartmann-Shack wavefront peripheral sensor, covering a visual field of horizontal 60° and vertical 36°. Relative peripheral refraction (RPR) was calculated by subtracting central from peripheral measurements.
After one year, SE increased more significantly in the 1/7 group compared to the 7/7 group (P < 0.001) and 2/7 group (P = 0.004); AL elongation was also greater in the 1/7 group compared to the 7/7 group (P < 0.001). In comparison with higher frequency groups, 1/7 group exhibited more myopic PR in the fovea and its vertical superior, inferior, and nasal retina; and less myopic RPR in the periphery retina after one-year (P < 0.05). Additionally, RPR in the 7/7 group demonstrated myopic shift across the entire retina, the 2/7 group in temporal and inferior retina, while the 1/7 group showed a hyperopic shift in the superior retina (P < 0.05). Moreover, myopic shift of RPR in the temporal retina is related to less myopia progression, notably in the 7/7 group (P < 0.05).
Atropine inhibits myopia progression in a frequency-dependent manner. The once-daily group showed the slowest myopia progression but exhibited more myopic shifts in RPR. Additionally, RPR in the temporal retina was related to myopia progression in all groups.
Chinese Clinical Trial Registry, ChiCTR2100043506. Registered 21 February 2021, https://www.chictr.org.cn/showproj.html?proj=122214.</description><subject>0.05% atropine eyedrops</subject><subject>Analysis</subject><subject>Atropine</subject><subject>Development and progression</subject><subject>Dosage and administration</subject><subject>Drug therapy</subject><subject>Health aspects</subject><subject>Medication compliance</subject><subject>Myopia</subject><subject>Myopia control</subject><subject>Ophthalmic solutions</subject><subject>Patient outcomes</subject><subject>Peripheral defocus</subject><subject>Pirenzepine</subject><subject>Sensors</subject><issn>2326-0254</issn><issn>2326-0254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNptUk1v1DAQjRCIVqV_gAOyhEBcskz8lYRLVVUUKlXiAmfLsce7rrJxsJOK_Hu8u6XalTh5_ObNk-f5FcXbClZV1cjPiYOUtATKSwDWihJeFOeUUZkhwV8e1WfFZUoPAFBV-VbT18UZa6ERrYDz4s9txN8zDmYpLY44WBwmgs6hmRIJjsAKxAeipxhGPyDBBW0uc2sg2yVjmowxrCOm5DOkB0tGjH7cYNQ9seiCmdMXsmelMYv6RyRpmu3ypnjldJ_w8um8KH7dfv158728__Ht7ub6vjScN1PpaGe4wJpJbp1jCLxhrnJ1w3KbCietFZ1DzSTTANbQShhtsek6y3lLLbso7g66NugHNUa_1XFRQXu1B0JcKx0nb3pUWshaa21rwRuOLW1l3VVS1o2ooK61yFpXB61x7rZoTfYqr3kietoZ_Eatw6PKzrcMJGSFT08KMWTb06S2Phnsez1gmJNi0MhWSNa2mfr-QF3r_DY_uJAlzY6urhtgvGKUysxa_Yeldx5svQkDOp_xk4GPRwMb1P20SaGfp_x_6ZRID0STvy5FdM97VqB2EVSHCKocQbWPoNrt9-7YoeeRf4FjfwGkzNZb</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Yang, Yuanfang</creator><creator>Xue, Minsong</creator><creator>Hao, Jiangdong</creator><creator>Lin, Zhenghua</creator><creator>Xi, Xiaoyun</creator><creator>Wu, Haoran</creator><creator>Wen, Longbo</creator><creator>Xu, Qinglin</creator><creator>Luo, Zhiwei</creator><creator>Ran, Guangyao</creator><creator>Artal, Pablo</creator><creator>Lan, Weizhong</creator><creator>Li, Xiaoning</creator><creator>Yang, Zhikuan</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4921-6825</orcidid></search><sort><creationdate>20240801</creationdate><title>Frequency-dependent effects of 0.05% atropine eyedrops on myopia progression and peripheral defocus: a prospective study</title><author>Yang, Yuanfang ; Xue, Minsong ; Hao, Jiangdong ; Lin, Zhenghua ; Xi, Xiaoyun ; Wu, Haoran ; Wen, Longbo ; Xu, Qinglin ; Luo, Zhiwei ; Ran, Guangyao ; Artal, Pablo ; Lan, Weizhong ; Li, Xiaoning ; Yang, Zhikuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-f2bc45e7364dff3e0483f1f78344825f6dd5bfea363a00dc215cade8bbd4492d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>0.05% atropine eyedrops</topic><topic>Analysis</topic><topic>Atropine</topic><topic>Development and progression</topic><topic>Dosage and administration</topic><topic>Drug therapy</topic><topic>Health aspects</topic><topic>Medication compliance</topic><topic>Myopia</topic><topic>Myopia control</topic><topic>Ophthalmic solutions</topic><topic>Patient outcomes</topic><topic>Peripheral defocus</topic><topic>Pirenzepine</topic><topic>Sensors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Yuanfang</creatorcontrib><creatorcontrib>Xue, Minsong</creatorcontrib><creatorcontrib>Hao, Jiangdong</creatorcontrib><creatorcontrib>Lin, Zhenghua</creatorcontrib><creatorcontrib>Xi, Xiaoyun</creatorcontrib><creatorcontrib>Wu, Haoran</creatorcontrib><creatorcontrib>Wen, Longbo</creatorcontrib><creatorcontrib>Xu, Qinglin</creatorcontrib><creatorcontrib>Luo, Zhiwei</creatorcontrib><creatorcontrib>Ran, Guangyao</creatorcontrib><creatorcontrib>Artal, Pablo</creatorcontrib><creatorcontrib>Lan, Weizhong</creatorcontrib><creatorcontrib>Li, Xiaoning</creatorcontrib><creatorcontrib>Yang, Zhikuan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Eye and vision (Novato, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Yuanfang</au><au>Xue, Minsong</au><au>Hao, Jiangdong</au><au>Lin, Zhenghua</au><au>Xi, Xiaoyun</au><au>Wu, Haoran</au><au>Wen, Longbo</au><au>Xu, Qinglin</au><au>Luo, Zhiwei</au><au>Ran, Guangyao</au><au>Artal, Pablo</au><au>Lan, Weizhong</au><au>Li, Xiaoning</au><au>Yang, Zhikuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Frequency-dependent effects of 0.05% atropine eyedrops on myopia progression and peripheral defocus: a prospective study</atitle><jtitle>Eye and vision (Novato, Calif.)</jtitle><addtitle>Eye Vis (Lond)</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>11</volume><issue>1</issue><spage>26</spage><epage>11</epage><pages>26-11</pages><artnum>26</artnum><issn>2326-0254</issn><eissn>2326-0254</eissn><abstract>Atropine, specifically 0.05% eyedrops, has proven effective in slowing myopia progression. This study aims to investigate peripheral refraction (PR) characteristics in myopic children treated with 0.05% atropine eyedrops at different frequencies.
One hundred thirty-eight myopic children completed this one-year prospective study, randomly assigned to once daily (7/7), twice per week (2/7), or once per week (1/7) groups. Spherical equivalent (SE) and axial length (AL) were measured. PR was assessed using a custom-made Hartmann-Shack wavefront peripheral sensor, covering a visual field of horizontal 60° and vertical 36°. Relative peripheral refraction (RPR) was calculated by subtracting central from peripheral measurements.
After one year, SE increased more significantly in the 1/7 group compared to the 7/7 group (P < 0.001) and 2/7 group (P = 0.004); AL elongation was also greater in the 1/7 group compared to the 7/7 group (P < 0.001). In comparison with higher frequency groups, 1/7 group exhibited more myopic PR in the fovea and its vertical superior, inferior, and nasal retina; and less myopic RPR in the periphery retina after one-year (P < 0.05). Additionally, RPR in the 7/7 group demonstrated myopic shift across the entire retina, the 2/7 group in temporal and inferior retina, while the 1/7 group showed a hyperopic shift in the superior retina (P < 0.05). Moreover, myopic shift of RPR in the temporal retina is related to less myopia progression, notably in the 7/7 group (P < 0.05).
Atropine inhibits myopia progression in a frequency-dependent manner. The once-daily group showed the slowest myopia progression but exhibited more myopic shifts in RPR. Additionally, RPR in the temporal retina was related to myopia progression in all groups.
Chinese Clinical Trial Registry, ChiCTR2100043506. Registered 21 February 2021, https://www.chictr.org.cn/showproj.html?proj=122214.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>39085950</pmid><doi>10.1186/s40662-024-00395-0</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-4921-6825</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 0.05% atropine eyedrops Analysis Atropine Development and progression Dosage and administration Drug therapy Health aspects Medication compliance Myopia Myopia control Ophthalmic solutions Patient outcomes Peripheral defocus Pirenzepine Sensors |
| title | Frequency-dependent effects of 0.05% atropine eyedrops on myopia progression and peripheral defocus: a prospective study |
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