Mushroom Poisoning-Related Cardiac Toxicity: A Case Report and Systematic Review

We encountered a case of mushroom intoxication complicated by "toxic-like" myocarditis. Because of the lack of systematized knowledge on this subject, we performed a systematic review of the literature on cardiac toxicity in mushroom poisoning (MP). The aim of this study was to identify an...

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Bibliographic Details
Published in:Toxins 2024-06, Vol.16 (6), p.265
Main Authors: Balice, Giuseppe, Boksebeld, Maxime, Barrier, Quentin, Boccalini, Sara, Kassai-Koupai, Behrouz, Paret, Nathalie, Grenet, Guillaume
Format: Article
Language:English
Subjects:
Adult
Algorithms
cardiac toxicity
Cardiotoxicity - etiology
Case reports
Congestive heart failure
Creatinine
ECG
Electrocardiography
Enzymes
Female
Heart diseases
Hemodialysis
Humans
Intensive care
Intoxication
Ischemia
Literature reviews
Magnetic resonance imaging
Male
Middle Aged
mushroom
Mushroom poisoning
Mushroom Poisoning - complications
Mushrooms
Myocarditis
Myocarditis - chemically induced
Patients
Plasma
Poisoning
Poisons
Systematic Review
Tachycardia
Toxicity
troponin
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Summary:We encountered a case of mushroom intoxication complicated by "toxic-like" myocarditis. Because of the lack of systematized knowledge on this subject, we performed a systematic review of the literature on cardiac toxicity in mushroom poisoning (MP). The aim of this study was to identify and describe the severity, the causal relationship, and the mushroom species involved in other reported cardiac events associated with MP. We included 39 studies in our review. We found 106 cases of cardiac events associated with MP, including 18 deaths. A wide variety of cardiac manifestations were reported, ranging from the simple elevation of cardiac enzymes (n = 61) to ventricular tachycardia (n = 14), acute heart failure (n = 18), and myocarditis (n = 7). Causal relationship between cardiac manifestations and mushroom poisoning was assessed for 42 patients, applying the algorithm validated by the French Toxicovigilance Coordination Committee. Twenty-three cases (54.8%) had a "possible" causal relationship, eight cases (19%) a "probable" relationship, and ten cases (23.8%) a "very probable" relationship. Several fungal genera were involved in reported cases, including but also rarer ones like and . In conclusion, we showed that cases of cardiac toxicity following MP have been documented in the existing literature, and for some of them, we assessed a strong causal relationship.
ISSN:2072-6651
2072-6651
DOI:10.3390/toxins16060265