Sudden Cardiac Death Risk Stratification and Prevention in Chagas Disease: A Non-systematic Review of the Literature

Chagas disease is an important public health problem in Latin America. However, migration and globalisation have resulted in the increased presence of Chagas disease worldwide. Sudden cardiac death is the leading cause of death in people with Chagas disease, most often due to ventricular fibrillatio...

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Bibliographic Details
Published in:Arrhythmia & electrophysiology review 2020-12, Vol.9 (4), p.175-181
Main Authors: Keegan, Roberto, Yeung, Cynthia, Baranchuk, Adrian
Format: Article
Language:English
Subjects:
Ablation
Asymptomatic
Cardiac arrhythmia
Cardiac stress tests
Cardiomyopathy
Cardiovascular disease
Catheters
Chagas disease
Clinical Arrhythmias
Clinical trials
Defibrillators
Ejection fraction
Heart failure
Infections
Medical prognosis
Mortality
Multivariate analysis
Systematic review
Ultrasonic imaging
Variables
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Summary:Chagas disease is an important public health problem in Latin America. However, migration and globalisation have resulted in the increased presence of Chagas disease worldwide. Sudden cardiac death is the leading cause of death in people with Chagas disease, most often due to ventricular fibrillation. Although more common in patients with documented ventricular arrhythmias, sudden cardiac death can also be the first manifestation of Chagas disease in patients with no previous symptoms or known heart failure. Major predictors of sudden cardiac death include cardiac arrest, sustained and non-sustained ventricular tachycardia, left ventricular dysfunction, syncope and bradycardia. The authors review the predictors and risk stratification score developed by Rassi et al. for death in Chagas heart disease. They also discuss the evidence for anti-arrhythmic drugs, catheter ablation, ICDs and pacemakers for the prevention of sudden cardiac death in these patients. Given the widespread global burden, understanding the risk stratification and prevention of sudden cardiac death in Chagas disease is of timely concern.
ISSN:2050-3369
2050-3377
DOI:10.15420/aer.2020.27