Downregulated GTCPH I/BH4 Pathway and Decreased Function of Circulating Endothelial Progenitor Cells and Their Relationship with Endothelial Dysfunction in Overweight Postmenopausal Women

Endothelial progenitor cells (EPCs) have endogenous endothelium-reparative potential, but obesity impairs EPCs. Overweight premenopausal women have a normal number of circulating EPCs with functional activity, but whether EPCs in overweight postmenopausal women can repair obesity-related endothelial...

Full description

Saved in:
Bibliographic Details
Published in:Stem cells international 2018-01, Vol.2018 (2018), p.1-11
Main Authors: Zeng, Haitao, Yan, Quanneng, Zhan, Hong, Hu, Da-Jun, He, Hao, Yao, Shun, Li, Xiao-Peng, Liu, Zhihao, Liao, Jinli, Huang, Zhenhua, Luo, Ying, Ren, Zi
Format: Article
Language:English
Subjects:
Body weight
Cardiovascular disease
Cells (biology)
Comparative analysis
Endothelium
Health risk assessment
Low density lipoprotein
Menopause
Nitric oxide
Obesity
Overweight
Post-menopause
Postmenopausal women
Progenitor cells
Sapropterin dihydrochloride
Signal transduction
Stem cells
Stretching
Therapeutic applications
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c635t-33d73bb056fccc8779e04136968ff02246635eed0b96ad3af8f9dedf839e18a93
cites cdi_FETCH-LOGICAL-c635t-33d73bb056fccc8779e04136968ff02246635eed0b96ad3af8f9dedf839e18a93
container_end_page 11
container_issue 2018
container_start_page 1
container_title Stem cells international
container_volume 2018
creator Zeng, Haitao
Yan, Quanneng
Zhan, Hong
Hu, Da-Jun
He, Hao
Yao, Shun
Li, Xiao-Peng
Liu, Zhihao
Liao, Jinli
Huang, Zhenhua
Luo, Ying
Ren, Zi
description Endothelial progenitor cells (EPCs) have endogenous endothelium-reparative potential, but obesity impairs EPCs. Overweight premenopausal women have a normal number of circulating EPCs with functional activity, but whether EPCs in overweight postmenopausal women can repair obesity-related endothelial damage requires further investigation. For this purpose, we examined the function and number of circulating EPCs, evaluated vascular endothelial function, and explored the underlying mechanism. Compared with normal weight or overweight age-matched men, postmenopausal women (overweight or normal weight) had a diminished number of circulating EPCs and impaired vascular endothelial function, as detected by flow-mediated dilatation. Moreover, GTCPH I expression and the nitric oxide level in overweight postmenopausal women and men were significantly decreased. Together, our findings demonstrate that the number or function of circulating EPCs and endothelial function, which is partially regulated by the GTCPH I/BH4 signaling pathway, is not preserved in overweight postmenopausal women. The GTCPH I/BH4 pathway in circulating EPCs may be a potential therapeutic target for endothelial injury in overweight postmenopausal women.
doi_str_mv 10.1155/2018/4756263
format article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_a56cdc0ea089409595175d68754fd695</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A587260546</galeid><doaj_id>oai_doaj_org_article_a56cdc0ea089409595175d68754fd695</doaj_id><sourcerecordid>A587260546</sourcerecordid><originalsourceid>FETCH-LOGICAL-c635t-33d73bb056fccc8779e04136968ff02246635eed0b96ad3af8f9dedf839e18a93</originalsourceid><addsrcrecordid>eNqNkktr3DAURk1paUKaXddFUCiFdhLZsiRrU0hn8oJAhpLS7oxGurIVPNJUsjPkt_XPVfPIY0oXlReS5XOP8KebZW9zfJTnlB4XOK-OS05ZwciLbD9nFR8JxquXj2v2cy87jPEWp0EELnHxOtsjGFNMOd_Pfk_80gVohk72oNH5zXh6gS6Pv16UaCr7dinvkXQaTUAFkDERZ4NTvfUOeYPGNqhVoXUNOnXa9y10VnZoGnwDzvY-oDF0XVwrblqwAX2DFe9dbO0CLW3f7hRO7qN58FuHru8gLME2bY-mPvZzcH4hh5jAHz69vMleGdlFONzOB9n3s9Ob8cXo6vr8cnxyNVKM0H5EiOZkNsOUGaVUxbkAXOaECVYZg4uiZAkD0HgmmNREmsoIDdpUREBeSUEOssuNV3t5Wy-CnctwX3tp6_WGD00tQ29VB7WkTGmFQeJKlFhQQXNOdboJWhrNBE2uLxvXYpjNQStwfZDdjnT3i7Nt3fi7muGS5QQnwcetIPhfA8S-ntuoUsrSgR9iXWBeUS5IThL6_i_01g_BpahWFM4pExw_UY1MP2Cd8elctZLWJ7TiBcO0ZIk6-geVHg1zq7wDY9P-TsGHZwUtyK5vo--G9eXvgp83oAo-xgDmMYwc16smr1dNXm-bPOHvngf4CD-0dAI-bYDWOi2X9j91kBgw8okuclKmvP8A5ZoOdA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2070156970</pqid></control><display><type>article</type><title>Downregulated GTCPH I/BH4 Pathway and Decreased Function of Circulating Endothelial Progenitor Cells and Their Relationship with Endothelial Dysfunction in Overweight Postmenopausal Women</title><source>Publicly Available Content Database</source><source>Wiley Open Access</source><source>PubMed Central</source><creator>Zeng, Haitao ; Yan, Quanneng ; Zhan, Hong ; Hu, Da-Jun ; He, Hao ; Yao, Shun ; Li, Xiao-Peng ; Liu, Zhihao ; Liao, Jinli ; Huang, Zhenhua ; Luo, Ying ; Ren, Zi</creator><contributor>Bihl, Ji C. ; Ji C Bihl</contributor><creatorcontrib>Zeng, Haitao ; Yan, Quanneng ; Zhan, Hong ; Hu, Da-Jun ; He, Hao ; Yao, Shun ; Li, Xiao-Peng ; Liu, Zhihao ; Liao, Jinli ; Huang, Zhenhua ; Luo, Ying ; Ren, Zi ; Bihl, Ji C. ; Ji C Bihl</creatorcontrib><description>Endothelial progenitor cells (EPCs) have endogenous endothelium-reparative potential, but obesity impairs EPCs. Overweight premenopausal women have a normal number of circulating EPCs with functional activity, but whether EPCs in overweight postmenopausal women can repair obesity-related endothelial damage requires further investigation. For this purpose, we examined the function and number of circulating EPCs, evaluated vascular endothelial function, and explored the underlying mechanism. Compared with normal weight or overweight age-matched men, postmenopausal women (overweight or normal weight) had a diminished number of circulating EPCs and impaired vascular endothelial function, as detected by flow-mediated dilatation. Moreover, GTCPH I expression and the nitric oxide level in overweight postmenopausal women and men were significantly decreased. Together, our findings demonstrate that the number or function of circulating EPCs and endothelial function, which is partially regulated by the GTCPH I/BH4 signaling pathway, is not preserved in overweight postmenopausal women. The GTCPH I/BH4 pathway in circulating EPCs may be a potential therapeutic target for endothelial injury in overweight postmenopausal women.</description><identifier>ISSN: 1687-966X</identifier><identifier>ISSN: 1687-9678</identifier><identifier>EISSN: 1687-9678</identifier><identifier>DOI: 10.1155/2018/4756263</identifier><identifier>PMID: 30050577</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Body weight ; Cardiovascular disease ; Cells (biology) ; Comparative analysis ; Endothelium ; Health risk assessment ; Low density lipoprotein ; Menopause ; Nitric oxide ; Obesity ; Overweight ; Post-menopause ; Postmenopausal women ; Progenitor cells ; Sapropterin dihydrochloride ; Signal transduction ; Stem cells ; Stretching ; Therapeutic applications</subject><ispartof>Stem cells international, 2018-01, Vol.2018 (2018), p.1-11</ispartof><rights>Copyright © 2018 Ying Luo et al.</rights><rights>COPYRIGHT 2018 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2018 Ying Luo et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2018 Ying Luo et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c635t-33d73bb056fccc8779e04136968ff02246635eed0b96ad3af8f9dedf839e18a93</citedby><cites>FETCH-LOGICAL-c635t-33d73bb056fccc8779e04136968ff02246635eed0b96ad3af8f9dedf839e18a93</cites><orcidid>0000-0001-7797-4135 ; 0000-0001-9541-9151 ; 0000-0002-7427-8596</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2070156970/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2070156970?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30050577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bihl, Ji C.</contributor><contributor>Ji C Bihl</contributor><creatorcontrib>Zeng, Haitao</creatorcontrib><creatorcontrib>Yan, Quanneng</creatorcontrib><creatorcontrib>Zhan, Hong</creatorcontrib><creatorcontrib>Hu, Da-Jun</creatorcontrib><creatorcontrib>He, Hao</creatorcontrib><creatorcontrib>Yao, Shun</creatorcontrib><creatorcontrib>Li, Xiao-Peng</creatorcontrib><creatorcontrib>Liu, Zhihao</creatorcontrib><creatorcontrib>Liao, Jinli</creatorcontrib><creatorcontrib>Huang, Zhenhua</creatorcontrib><creatorcontrib>Luo, Ying</creatorcontrib><creatorcontrib>Ren, Zi</creatorcontrib><title>Downregulated GTCPH I/BH4 Pathway and Decreased Function of Circulating Endothelial Progenitor Cells and Their Relationship with Endothelial Dysfunction in Overweight Postmenopausal Women</title><title>Stem cells international</title><addtitle>Stem Cells Int</addtitle><description>Endothelial progenitor cells (EPCs) have endogenous endothelium-reparative potential, but obesity impairs EPCs. Overweight premenopausal women have a normal number of circulating EPCs with functional activity, but whether EPCs in overweight postmenopausal women can repair obesity-related endothelial damage requires further investigation. For this purpose, we examined the function and number of circulating EPCs, evaluated vascular endothelial function, and explored the underlying mechanism. Compared with normal weight or overweight age-matched men, postmenopausal women (overweight or normal weight) had a diminished number of circulating EPCs and impaired vascular endothelial function, as detected by flow-mediated dilatation. Moreover, GTCPH I expression and the nitric oxide level in overweight postmenopausal women and men were significantly decreased. Together, our findings demonstrate that the number or function of circulating EPCs and endothelial function, which is partially regulated by the GTCPH I/BH4 signaling pathway, is not preserved in overweight postmenopausal women. The GTCPH I/BH4 pathway in circulating EPCs may be a potential therapeutic target for endothelial injury in overweight postmenopausal women.</description><subject>Body weight</subject><subject>Cardiovascular disease</subject><subject>Cells (biology)</subject><subject>Comparative analysis</subject><subject>Endothelium</subject><subject>Health risk assessment</subject><subject>Low density lipoprotein</subject><subject>Menopause</subject><subject>Nitric oxide</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Post-menopause</subject><subject>Postmenopausal women</subject><subject>Progenitor cells</subject><subject>Sapropterin dihydrochloride</subject><subject>Signal transduction</subject><subject>Stem cells</subject><subject>Stretching</subject><subject>Therapeutic applications</subject><issn>1687-966X</issn><issn>1687-9678</issn><issn>1687-9678</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNkktr3DAURk1paUKaXddFUCiFdhLZsiRrU0hn8oJAhpLS7oxGurIVPNJUsjPkt_XPVfPIY0oXlReS5XOP8KebZW9zfJTnlB4XOK-OS05ZwciLbD9nFR8JxquXj2v2cy87jPEWp0EELnHxOtsjGFNMOd_Pfk_80gVohk72oNH5zXh6gS6Pv16UaCr7dinvkXQaTUAFkDERZ4NTvfUOeYPGNqhVoXUNOnXa9y10VnZoGnwDzvY-oDF0XVwrblqwAX2DFe9dbO0CLW3f7hRO7qN58FuHru8gLME2bY-mPvZzcH4hh5jAHz69vMleGdlFONzOB9n3s9Ob8cXo6vr8cnxyNVKM0H5EiOZkNsOUGaVUxbkAXOaECVYZg4uiZAkD0HgmmNREmsoIDdpUREBeSUEOssuNV3t5Wy-CnctwX3tp6_WGD00tQ29VB7WkTGmFQeJKlFhQQXNOdboJWhrNBE2uLxvXYpjNQStwfZDdjnT3i7Nt3fi7muGS5QQnwcetIPhfA8S-ntuoUsrSgR9iXWBeUS5IThL6_i_01g_BpahWFM4pExw_UY1MP2Cd8elctZLWJ7TiBcO0ZIk6-geVHg1zq7wDY9P-TsGHZwUtyK5vo--G9eXvgp83oAo-xgDmMYwc16smr1dNXm-bPOHvngf4CD-0dAI-bYDWOi2X9j91kBgw8okuclKmvP8A5ZoOdA</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Zeng, Haitao</creator><creator>Yan, Quanneng</creator><creator>Zhan, Hong</creator><creator>Hu, Da-Jun</creator><creator>He, Hao</creator><creator>Yao, Shun</creator><creator>Li, Xiao-Peng</creator><creator>Liu, Zhihao</creator><creator>Liao, Jinli</creator><creator>Huang, Zhenhua</creator><creator>Luo, Ying</creator><creator>Ren, Zi</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley &amp; Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-7797-4135</orcidid><orcidid>https://orcid.org/0000-0001-9541-9151</orcidid><orcidid>https://orcid.org/0000-0002-7427-8596</orcidid></search><sort><creationdate>20180101</creationdate><title>Downregulated GTCPH I/BH4 Pathway and Decreased Function of Circulating Endothelial Progenitor Cells and Their Relationship with Endothelial Dysfunction in Overweight Postmenopausal Women</title><author>Zeng, Haitao ; Yan, Quanneng ; Zhan, Hong ; Hu, Da-Jun ; He, Hao ; Yao, Shun ; Li, Xiao-Peng ; Liu, Zhihao ; Liao, Jinli ; Huang, Zhenhua ; Luo, Ying ; Ren, Zi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c635t-33d73bb056fccc8779e04136968ff02246635eed0b96ad3af8f9dedf839e18a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Body weight</topic><topic>Cardiovascular disease</topic><topic>Cells (biology)</topic><topic>Comparative analysis</topic><topic>Endothelium</topic><topic>Health risk assessment</topic><topic>Low density lipoprotein</topic><topic>Menopause</topic><topic>Nitric oxide</topic><topic>Obesity</topic><topic>Overweight</topic><topic>Post-menopause</topic><topic>Postmenopausal women</topic><topic>Progenitor cells</topic><topic>Sapropterin dihydrochloride</topic><topic>Signal transduction</topic><topic>Stem cells</topic><topic>Stretching</topic><topic>Therapeutic applications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zeng, Haitao</creatorcontrib><creatorcontrib>Yan, Quanneng</creatorcontrib><creatorcontrib>Zhan, Hong</creatorcontrib><creatorcontrib>Hu, Da-Jun</creatorcontrib><creatorcontrib>He, Hao</creatorcontrib><creatorcontrib>Yao, Shun</creatorcontrib><creatorcontrib>Li, Xiao-Peng</creatorcontrib><creatorcontrib>Liu, Zhihao</creatorcontrib><creatorcontrib>Liao, Jinli</creatorcontrib><creatorcontrib>Huang, Zhenhua</creatorcontrib><creatorcontrib>Luo, Ying</creatorcontrib><creatorcontrib>Ren, Zi</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health &amp; Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Stem cells international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zeng, Haitao</au><au>Yan, Quanneng</au><au>Zhan, Hong</au><au>Hu, Da-Jun</au><au>He, Hao</au><au>Yao, Shun</au><au>Li, Xiao-Peng</au><au>Liu, Zhihao</au><au>Liao, Jinli</au><au>Huang, Zhenhua</au><au>Luo, Ying</au><au>Ren, Zi</au><au>Bihl, Ji C.</au><au>Ji C Bihl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Downregulated GTCPH I/BH4 Pathway and Decreased Function of Circulating Endothelial Progenitor Cells and Their Relationship with Endothelial Dysfunction in Overweight Postmenopausal Women</atitle><jtitle>Stem cells international</jtitle><addtitle>Stem Cells Int</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>1687-966X</issn><issn>1687-9678</issn><eissn>1687-9678</eissn><abstract>Endothelial progenitor cells (EPCs) have endogenous endothelium-reparative potential, but obesity impairs EPCs. Overweight premenopausal women have a normal number of circulating EPCs with functional activity, but whether EPCs in overweight postmenopausal women can repair obesity-related endothelial damage requires further investigation. For this purpose, we examined the function and number of circulating EPCs, evaluated vascular endothelial function, and explored the underlying mechanism. Compared with normal weight or overweight age-matched men, postmenopausal women (overweight or normal weight) had a diminished number of circulating EPCs and impaired vascular endothelial function, as detected by flow-mediated dilatation. Moreover, GTCPH I expression and the nitric oxide level in overweight postmenopausal women and men were significantly decreased. Together, our findings demonstrate that the number or function of circulating EPCs and endothelial function, which is partially regulated by the GTCPH I/BH4 signaling pathway, is not preserved in overweight postmenopausal women. The GTCPH I/BH4 pathway in circulating EPCs may be a potential therapeutic target for endothelial injury in overweight postmenopausal women.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>30050577</pmid><doi>10.1155/2018/4756263</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-7797-4135</orcidid><orcidid>https://orcid.org/0000-0001-9541-9151</orcidid><orcidid>https://orcid.org/0000-0002-7427-8596</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1687-966X
ispartof Stem cells international, 2018-01, Vol.2018 (2018), p.1-11
issn 1687-966X
1687-9678
1687-9678
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_a56cdc0ea089409595175d68754fd695
source Publicly Available Content Database; Wiley Open Access; PubMed Central
subjects Body weight
Cardiovascular disease
Cells (biology)
Comparative analysis
Endothelium
Health risk assessment
Low density lipoprotein
Menopause
Nitric oxide
Obesity
Overweight
Post-menopause
Postmenopausal women
Progenitor cells
Sapropterin dihydrochloride
Signal transduction
Stem cells
Stretching
Therapeutic applications
title Downregulated GTCPH I/BH4 Pathway and Decreased Function of Circulating Endothelial Progenitor Cells and Their Relationship with Endothelial Dysfunction in Overweight Postmenopausal Women
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T15%3A38%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Downregulated%20GTCPH%20I/BH4%20Pathway%20and%20Decreased%20Function%20of%20Circulating%20Endothelial%20Progenitor%20Cells%20and%20Their%20Relationship%20with%20Endothelial%20Dysfunction%20in%20Overweight%20Postmenopausal%20Women&rft.jtitle=Stem%20cells%20international&rft.au=Zeng,%20Haitao&rft.date=2018-01-01&rft.volume=2018&rft.issue=2018&rft.spage=1&rft.epage=11&rft.pages=1-11&rft.issn=1687-966X&rft.eissn=1687-9678&rft_id=info:doi/10.1155/2018/4756263&rft_dat=%3Cgale_doaj_%3EA587260546%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c635t-33d73bb056fccc8779e04136968ff02246635eed0b96ad3af8f9dedf839e18a93%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2070156970&rft_id=info:pmid/30050577&rft_galeid=A587260546&rfr_iscdi=true