Genetic diversity of Coxsackievirus A21 associated with sporadic cases of acute respiratory infections in Malaysia

Coxsackievirus A21 (CVA21), a member of Enterovirus C from the Picornaviridae family, has been associated with respiratory illnesses in humans. A molecular epidemiological investigation of CVA21 was conducted among patients presenting with acute upper respiratory illnesses in the ambulatory settings...

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Bibliographic Details
Published in:BMC infectious diseases 2021-05, Vol.21 (1), p.446-446, Article 446
Main Authors: Supian, Nur Izzati, Ng, Kim Tien, Chook, Jack Bee, Takebe, Yutaka, Chan, Kok Gan, Tee, Kok Keng
Format: Article
Language:English
Subjects:
Acute respiratory tract infections
Causes of
Coxsackievirus
Coxsackieviruses
Distribution
Enterovirus
Enteroviruses
Epidemics
Epidemiology
Gene mapping
Genetic aspects
Genetic diversity
Genomes
Health surveillance
Illnesses
Infections
Infectious diseases
Outbreak
Patients
Phylogenetics
Phylogeny
Respiratory diseases
Respiratory tract infection
Respiratory tract infections
Seasonal distribution
Taxonomy
VP1 protein
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Summary:Coxsackievirus A21 (CVA21), a member of Enterovirus C from the Picornaviridae family, has been associated with respiratory illnesses in humans. A molecular epidemiological investigation of CVA21 was conducted among patients presenting with acute upper respiratory illnesses in the ambulatory settings between 2012 and 2014 in Kuala Lumpur, Malaysia. Epidemiological surveillance of acute respiratory infections (n = 3935) showed low-level detection of CVA21 (0.08%, 1.4 cases/year) in Kuala Lumpur, with no clear seasonal distribution. Phylogenetic analysis of the new complete genomes showed close relationship with CVA21 strains from China and the United States. Spatio-temporal mapping of the VP1 gene determined 2 major clusters circulating worldwide, with inter-country lineage migration and strain replacement occurring over time. The study highlights the emerging role of CVA21 in causing sporadic acute respiratory outbreaks.
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-021-06148-x