5-HT7 receptor signaling: improved therapeutic strategy in gut disorders

Serotonin (5-hydroxytryptamine; 5-HT) is most commonly known for its role as a neurotransmitter in the central nervous system (CNS). However, the majority of the body's 5-HT is produced in the gut by enterochromaffin (EC) cells. Alterations in 5-HT signaling have been associated with various gu...

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Bibliographic Details
Published in:Frontiers in behavioral neuroscience 2014-12, Vol.8, p.396-396
Main Authors: Kim, Janice J, Khan, Waliul I
Format: Article
Language:English
Subjects:
5-HT
Central nervous system
Colitis
Colon
Digestive system
Gastrointestinal tract
Infections
Inflammation
Inflammatory bowel disease
Inflammatory bowel diseases
Inflammatory diseases
Intestine
Irritable bowel syndrome
Keywords- serotonin
Neuroscience
Serotonin
serotonin receptor type 7
Serotonin receptors
Serotonin S7 receptors
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Summary:Serotonin (5-hydroxytryptamine; 5-HT) is most commonly known for its role as a neurotransmitter in the central nervous system (CNS). However, the majority of the body's 5-HT is produced in the gut by enterochromaffin (EC) cells. Alterations in 5-HT signaling have been associated with various gut disorders including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and enteric infections. Recently, our studies have identified a key role for 5-HT in the pathogenesis of experimental colitis. 5-HT7 receptors are expressed in the gut and very recently, we have shown evidence of 5-HT7 receptor expression on intestinal immune cells and demonstrated a key role for 5-HT7 receptors in generation of experimental colitis. This review summarizes the key findings of these studies and provides a comprehensive overview of our current knowledge of the 5-HT7 receptor in terms of its pathophysiological relevance and therapeutic potential in intestinal inflammatory conditions, such as IBD.
ISSN:1662-5153
1662-5153
DOI:10.3389/fnbeh.2014.00396