The Leydig Steroid Cell Tumor in a Postmenopausal Woman with Clinical and Biochemical Hyperandrogenism: A Case Report

Leydig cell tumors (LCTs) refer to tumors of the stroma of the genital strand, which are found mainly in postmenopausal women. The diagnosis of LCTs in postmenopausal women is associated with specific difficulties and is based on the identification of hyperandrogenism with clinical manifestations of...

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Bibliographic Details
Published in:Metabolites 2022-07, Vol.12 (7), p.620
Main Authors: Suturina, Larisa V, Sharifulin, Eldar M, Sharifulin, Maharam A, Lazareva, Ludmila M, Danusevich, Irina N, Ievleva, Kseniia D, Nadeliaeva, Iana G
Format: Article
Language:English
Subjects:
Abdomen
Acne
Adrenal glands
Alopecia
Androgens
Baldness
Biopsy
Blood pressure
Care and treatment
Case Report
Case reports
Complications and side effects
Diagnosis
Differential diagnosis
Gonadal disorders
Gynecology
Hair
Health aspects
hirsutism
hyperandrogenism
Laboratories
Laparoscopy
Leydig cell tumors (LCTs)
Obesity
ovarian tumor
Ovarian tumors
Ovariectomy
Ovaries
Patients
Post-menopause
Postmenopausal women
postmenopause
Risk factors
Steroids
Stroma
Surgery
Testosterone
Tumors
Ultrasonic imaging
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Summary:Leydig cell tumors (LCTs) refer to tumors of the stroma of the genital strand, which are found mainly in postmenopausal women. The diagnosis of LCTs in postmenopausal women is associated with specific difficulties and is based on the identification of hyperandrogenism with clinical manifestations of virilization, which has an erased picture in postmenopausal women. LCTs require differential diagnosis with other causes of hyperandrogenism. We present the clinical case of a 55-year-old Russian postmenopausal patient with LCTs of the right ovary, significantly increased levels of androgens, and rapidly progressive clinical signs of hyperandrogenism. The patient underwent laparoscopic bilateral salpingo-oophorectomy, and the androgen indices reached average values by the first and third month after surgery. This case demonstrates that LCTs are often benign with a good prognosis and normalization of the clinical and laboratory manifestations of hyperandrogenism after surgical treatment. The type of surgery performed (bilateral salpingo-oophorectomy rather than unilateral) is recommended as the treatment of choice for LCTs in postmenopausal patients.
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo12070620