Anti-Amnesic Effect of Synbiotic Supplementation Containing Corni fructus and Limosilactobacillus reuteri in DSS-Induced Colitis Mice

This study was conducted to compare the synbiotic activity between Corni fructus (C. fructus) and Limosilactobacillus reuteri (L. reuteri) on dextran sulfate sodium (DSS)-induced colitis and cognitive dysfunction in C57BL/6 mice. C. fructus (as prebiotics, PRE), L. reuteri (as probiotics, PRO), and...

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Published in:International journal of molecular sciences 2022-12, Vol.24 (1), p.90
Main Authors: Lee, Hyo Lim, Kim, Jong Min, Moon, Jong Hyun, Kim, Min Ji, Jeong, Hye Rin, Go, Min Ji, Kim, Hyun-Jin, Eo, Hyun Ji, Lee, Uk, Heo, Ho Jin
Format: Article
Language:English
Subjects:
Amyloid beta-Peptides - adverse effects
Animals
anti-inflammation
cognitive impairment
Colitis - chemically induced
Colitis - drug therapy
Colon - pathology
Corni fuctus
Cornus
Dextran Sulfate - toxicity
Disease Models, Animal
gut microbiota
gut-brain axis
Limosilactobacillus reuteri
Mice
Mice, Inbred C57BL
Synbiotics
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Summary:This study was conducted to compare the synbiotic activity between Corni fructus (C. fructus) and Limosilactobacillus reuteri (L. reuteri) on dextran sulfate sodium (DSS)-induced colitis and cognitive dysfunction in C57BL/6 mice. C. fructus (as prebiotics, PRE), L. reuteri (as probiotics, PRO), and synbiotics (as a mixture of L. reuteri and C. fructus, SYN) were fed to mice for 3 weeks. Consumption of PRE, PRO, and SYN ameliorated colitis symptoms in body weight, large intestinal length, and serum albumin level. Moreover, SYN showed a synergistic effect on intestinal permeability and intestinal anti-inflammation response. Also, SYN significantly improved cognitive function as a result of measuring the Y-maze and passive avoidance tests in DSS-induced behavioral disorder mice. Especially, SYN also restored memory function by increasing the cholinergic system and reducing tau and amyloid β pathology. In addition, PRE, PRO, and SYN ameliorated dysbiosis by regulating the gut microbiota and the concentration of short-chain fatty acids (SCFAs) in feces. The bioactive compounds of C. fructus were identified with quinic acid, morroniside, loganin, and cornuside, using ultra-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS2). In conclusion, synbiotic supplementation alleviated DSS-induced colitis and cognitive dysfunction by modulating gut microbiota, proinflammatory cytokines, and SCFAs production.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24010090