Neurological Disease in Lupus: Toward a Personalized Medicine Approach

The brain and nervous system are important targets for immune-mediated damage in systemic lupus erythematosus (SLE), resulting in a complex spectrum of neurological syndromes. Defining nervous system disease in lupus poses significant challenges. Among the difficulties to be addressed are a diversit...

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Bibliographic Details
Published in:Frontiers in immunology 2018-06, Vol.9, p.1146-1146
Main Authors: McGlasson, Sarah, Wiseman, Stewart, Wardlaw, Joanna, Dhaun, Neeraj, Hunt, David P J
Format: Article
Language:English
Subjects:
Animals
Biomarkers
Combined Modality Therapy
Diagnosis, Differential
Diagnostic Imaging
Disease Management
Disease Susceptibility
Humans
Immunology
interferon type I
lupus erythematosus
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - genetics
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - metabolism
Nervous System Diseases - diagnosis
Nervous System Diseases - etiology
Nervous System Diseases - therapy
neurolupus
personalized medicine
Precision Medicine
systemic
targeted therapy
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Summary:The brain and nervous system are important targets for immune-mediated damage in systemic lupus erythematosus (SLE), resulting in a complex spectrum of neurological syndromes. Defining nervous system disease in lupus poses significant challenges. Among the difficulties to be addressed are a diversity of clinical manifestations and a lack of understanding of their mechanistic basis. However, despite these challenges, progress has been made in the identification of pathways which contribute to neurological disease in SLE. Understanding the molecular pathogenesis of neurological disease in lupus will inform both classification and approaches to clinical trials.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2018.01146