Ribonucleic acid interference induced gene knockdown

Despite major advances in periodontal regeneration over the past three decades, complete regeneration of the lost periodontium on a regular and predictable basis in humans has still remained elusive. The identification of stem cells in the periodontal ligament together with the growing concept of ti...

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Bibliographic Details
Published in:Journal of Indian Society of Periodontology 2013-07, Vol.17 (4), p.417-422
Main Authors: Gottumukkala, Sruthima, Dwarakanath, C, Sudarsan, Sabitha
Format: Article
Language:English
Subjects:
Disease
Enzymes
Gene expression
Gene knock down
Gene silencing
Genes
Genetic aspects
Health aspects
Immune system
Metabolic disorders
Methods
periodontal regeneration
Physiological aspects
Proteins
Regeneration (Biology)
Review
ribonucleic acid interference
RNA
small interfering ribonucleic acid
Tissue engineering
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Summary:Despite major advances in periodontal regeneration over the past three decades, complete regeneration of the lost periodontium on a regular and predictable basis in humans has still remained elusive. The identification of stem cells in the periodontal ligament together with the growing concept of tissue engineering has opened new vistas in periodontal regenerative medicine. In this regard, ribonucleic acid interference (RNAi) opens a new gate way for a novel RNA based approach in periodontal management. This paper aims to summarize the current opinion on the mechanisms underlying RNAi, in vitro and in vivo existing applications in the dental research, which could lead to their future use in periodontal regeneration.
ISSN:0972-124X
0975-1580
DOI:10.4103/0972-124X.118309