MMP-13 enzyme and pH responsive theranostic nanoplatform for osteoarthritis

Stimulus-responsive therapy permits precise control of therapeutic effect only at lesion of interest, which determines it a promising method for diagnosis and imaging-guided precision therapy. The acid environment and overexpressed matrix metalloproteinases-13 (MMP-13) are typical markers in osteoar...

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Published in:Journal of nanobiotechnology 2020-08, Vol.18 (1), p.117-14, Article 117
Main Authors: Lan, Qiumei, Lu, Rongbin, Chen, Haimin, Pang, Yunfen, Xiong, Feng, Shen, Chong, Qin, Zainen, Zheng, Li, Xu, Guojie, Zhao, Jinmin
Format: Article
Language:English
Subjects:
Animals
Anti-inflammatory agents
Antiarthritic agents
Arthritis
Benzofurans
Biocompatibility
Biodynamics
Biomedical materials
Cartilage
Cartilage diseases
Cartilage targeting
Cells, Cultured
Chondrocytes - metabolism
Cognitive enhancement
Collagenase 3
Coumarins
Cytotoxicity
Diagnosis
Disease
Drug delivery
Drug delivery systems
Drugs
Enzymes
Gene expression
Health aspects
Herbal medicine
Hydrogen-Ion Concentration
Inflammation
Matrix metalloproteinase
Matrix Metalloproteinase 13 - metabolism
Matrix metalloproteinases
Mice
Mice, Inbred C57BL
Micelles
MMP-13/pH sensitive
Osteoarthritis
Osteoarthritis - metabolism
Peptides
pH effects
Theranostic Nanomedicine - methods
Theranostics
Traditional Chinese medicine
Vehicles
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cited_by cdi_FETCH-LOGICAL-c597t-d000a97a0dfa10808ea919682ec185d29afcc53285b2b6dea96fb4ea33f200053
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creator Lan, Qiumei
Lu, Rongbin
Chen, Haimin
Pang, Yunfen
Xiong, Feng
Shen, Chong
Qin, Zainen
Zheng, Li
Xu, Guojie
Zhao, Jinmin
description Stimulus-responsive therapy permits precise control of therapeutic effect only at lesion of interest, which determines it a promising method for diagnosis and imaging-guided precision therapy. The acid environment and overexpressed matrix metalloproteinases-13 (MMP-13) are typical markers in osteoarthritis (OA), which enables the development of stimulus-responsive drug delivery system with high specificity for OA. We herein demonstrate a nano-micelle based stimuli-responsive theranostic strategy with reporting and drug release controlled by acidic pH and MMP-13 for OA therapy. Such nanoplatform is incorporated with a motif specifically targeting on cartilage, a motif responsive to matrix metalloproteinases-13 to specifically report OA condition and biodynamics of nano-micelles, an anti-inflammatory drug (e.g., psoralidin (PSO)) from traditional Chinese medicine, and a biocompatible polymeric skeleton for sustainable drug release in response to the acidic OA condition. The high effectiveness of this targeted precision therapy is demonstrated comprehensively by both in vitro and vivo evidences.
doi_str_mv 10.1186/s12951-020-00666-7
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subjects Animals
Anti-inflammatory agents
Antiarthritic agents
Arthritis
Benzofurans
Biocompatibility
Biodynamics
Biomedical materials
Cartilage
Cartilage diseases
Cartilage targeting
Cells, Cultured
Chondrocytes - metabolism
Cognitive enhancement
Collagenase 3
Coumarins
Cytotoxicity
Diagnosis
Disease
Drug delivery
Drug delivery systems
Drugs
Enzymes
Gene expression
Health aspects
Herbal medicine
Hydrogen-Ion Concentration
Inflammation
Matrix metalloproteinase
Matrix Metalloproteinase 13 - metabolism
Matrix metalloproteinases
Mice
Mice, Inbred C57BL
Micelles
MMP-13/pH sensitive
Osteoarthritis
Osteoarthritis - metabolism
Peptides
pH effects
Theranostic Nanomedicine - methods
Theranostics
Traditional Chinese medicine
Vehicles
title MMP-13 enzyme and pH responsive theranostic nanoplatform for osteoarthritis
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