The possible molecular mechanisms of farnesol on the antifungal resistance of C. albicans biofilms: the regulation of CYR1 and PDE2

Farnesol has potential antifungal activity against Candida albicans biofilms, but the molecular mechanism of this activity is still unclear. Farnesol inhibits hyphal growth by regulating the cyclic AMP (cAMP) signalling pathway in C. albicans, and CYR1 and PDE2 regulate a pair of enzymes that are di...

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Bibliographic Details
Published in:BMC microbiology 2018-12, Vol.18 (1), p.203-203, Article 203
Main Authors: Chen, Shengyan, Xia, Jinping, Li, Chengxi, Zuo, Lulu, Wei, Xin
Format: Article
Language:English
Subjects:
Amphotericin B
Analysis
Antifungal activity
Antifungal agents
Biofilms
Candida albicans
Candida albicans biofilms
Candidiasis
Caspofungin
Cyclic AMP
CYR1
Enzymes
Farnesol
Fungicides
Gene expression
Health aspects
HIV patients
Hyphae
Infections
Intracellular
Itraconazole
Kinases
Microbial mats
Molecular mechanics
Molecular modelling
Morphogenesis
PDE2
Planktonic cells
Proteins
Resistance
Risk factors
Signal transduction
Terbinafine
Yeast
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Summary:Farnesol has potential antifungal activity against Candida albicans biofilms, but the molecular mechanism of this activity is still unclear. Farnesol inhibits hyphal growth by regulating the cyclic AMP (cAMP) signalling pathway in C. albicans, and CYR1 and PDE2 regulate a pair of enzymes that are directly responsible for cAMP synthesis and degradation. Here, we hypothesize that farnesol enhances the antifungal susceptibility of C. albicans biofilms by regulating CYR1 and PDE2. The resistance of the CYR1- and PDE2-overexpressing strains to caspofungin, itraconazole and terbinafine was increased in planktonic cells, and that to amphotericin B was increased in biofilms. Meanwhile, the biofilms of the CYR1- and PDE2-overexpressing strains were thicker (all p 
ISSN:1471-2180
1471-2180
DOI:10.1186/s12866-018-1344-z