Effect of CPAP on cardiovascular events in minimally symptomatic OSA: long-term follow-up of the MOSAIC randomised controlled trial

The effect of continuous positive airway pressure (CPAP) on cardiovascular events is uncertain in minimally symptomatic obstructive sleep apnoea. Previous 2-year follow-up data from the Multicentre Obstructive Sleep Apnoea Intervention Cardiovascular (MOSAIC) trial showed a marginal reduction in car...

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Bibliographic Details
Published in:BMJ open respiratory research 2020-09, Vol.7 (1), p.e000742
Main Authors: Tang, Ivan, Turnbull, Chris D, Sen, Dushendree, Craig, Sonya, Kohler, Malcolm, Stradling, John R
Format: Article
Language:English
Subjects:
Body mass index
Cardiac arrhythmia
Continuous positive airway pressure
Hypertension
Ischemia
Patients
Perspective
Sleep apnea
sleep apnoea
systemic disease and lungs
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Summary:The effect of continuous positive airway pressure (CPAP) on cardiovascular events is uncertain in minimally symptomatic obstructive sleep apnoea. Previous 2-year follow-up data from the Multicentre Obstructive Sleep Apnoea Intervention Cardiovascular (MOSAIC) trial showed a marginal reduction in cardiovascular events with CPAP therapy. We now present long-term MOSAIC study follow-up data. Median (first quartile, third quartile) follow-up was 5.0 (2.2, 5.0) and 3.7 (1.5, 5.0) years for CPAP and standard care, respectively. Compared to standard care, CPAP had no statistically significant effect on the risk of cardiovascular events (HR=0.83, p=0.54, 95% CI 0.46–1.51).
ISSN:2052-4439
2052-4439
DOI:10.1136/bmjresp-2020-000742