Therapies from Thiopeptides

The first part of this contribution describes solutions that were developed to achieve progressively more efficient syntheses of the thiopeptide natural products, micrococcins P1 and P2 (MP1–MP2), with an eye toward exploring their potential as a source of new antibiotics. Such efforts enabled inves...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-11, Vol.28 (22), p.7579
Main Authors: Hwang, Hee-Jong, Ciufolini, Marco A
Format: Article
Language:English
Subjects:
Acids
Alcohol
Antibacterial agents
Antibiotics
c-kit
Chemistry
Clinical trials
Clostridioides difficile
COVID
Fidaxomicin
Health aspects
Ixabepilone
kinase inhibitors
Metronidazole
micrococcin P1
Natural products
Nilotinib
Pharmaceutical sciences
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Summary:The first part of this contribution describes solutions that were developed to achieve progressively more efficient syntheses of the thiopeptide natural products, micrococcins P1 and P2 (MP1–MP2), with an eye toward exploring their potential as a source of new antibiotics. Such efforts enabled investigations on the medicinal chemistry of those antibiotics, and inspired the development of the kinase inhibitor, Masitinib®, two candidate oncology drugs, and new antibacterial agents. The studies that produced such therapeutic resources are detailed in the second part. True to the theme of this issue, “Organic Synthesis and Medicinal Chemistry: Two Inseparable Partners”, an important message is that the above advances would have never materialized without the support of curiosity-driven, academic synthetic organic chemistry: a beleaguered science that nonetheless has been—and continues to be—instrumental to progress in the biomedical field.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28227579