The bacterial pathogenesis and treatment of pouchitis

Restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis is the operation of choice for patients with ulcerative colitis. Pouchitis is the most common cause of pouch dysfunction. Although the pathogenesis of this disease is not well understood, bacteria have been implicated in the disease...

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Bibliographic Details
Published in:Therapeutic Advances in Gastroenterology 2010-11, Vol.3 (6), p.335-348
Main Authors: McLaughlin, S.D., Clark, S.K., Tekkis, P.P., Nicholls, R.J., Ciclitira, P.J.
Format: Article
Language:English
Subjects:
Anastomosis
Antibiotics
Bacteria
Reviews
Ulcerative colitis
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Summary:Restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis is the operation of choice for patients with ulcerative colitis. Pouchitis is the most common cause of pouch dysfunction. Although the pathogenesis of this disease is not well understood, bacteria have been implicated in the disease process. Numerous bacterial studies have been reported over the last 25 years with few unifying findings. In addition, many different treatments for pouchitis have been reported with varying results. Antibiotic treatment remains the most studied and is the mainstay of treatment. In this article we review the aetiology of pouchitis and the evidenced-based treatment options.
ISSN:1756-283X
1756-2848
1756-2848
DOI:10.1177/1756283X10370611