Zebrafish as a Potential Model for Neurodegenerative Diseases: A Focus on Toxic Metals Implications

In the last century, industrial activities increased and caused multiple health problems for humans and animals. At this moment, heavy metals are considered the most harmful substances for their effects on organisms and humans. The impact of these toxic metals, which have no biological role, poses a...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-02, Vol.24 (4), p.3428
Main Authors: Paduraru, Emanuela, Iacob, Diana, Rarinca, Viorica, Plavan, Gabriel, Ureche, Dorel, Jijie, Roxana, Nicoara, Mircea
Format: Article
Language:English
Subjects:
Alzheimer's disease
Analysis
Animal models
Brain research
Danio rerio
Dopamine
Embryos
Heavy metals
Laboratories
Nervous system
Nervous system diseases
neurodegenerative diseases
Neurological disorders
Neurophysiology
Neurosciences
neurotoxicity
Parkinson's disease
Review
Spinal cord
Toxicity
Zebrafish
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Summary:In the last century, industrial activities increased and caused multiple health problems for humans and animals. At this moment, heavy metals are considered the most harmful substances for their effects on organisms and humans. The impact of these toxic metals, which have no biological role, poses a considerable threat and is associated with several health problems. Heavy metals can interfere with metabolic processes and can sometimes act as pseudo-elements. The zebrafish is an animal model progressively used to expose the toxic effects of diverse compounds and to find treatments for different devastating diseases that human beings are currently facing. This review aims to analyse and discuss the value of zebrafish as animal models used in neurological conditions, such as Alzheimer's disease (AD), and Parkinson's disease (PD), particularly in terms of the benefits of animal models and the limitations that exist.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24043428