Epidemiology, Mechanisms of Resistance and Treatment Algorithm for Infections Due to Carbapenem-Resistant Gram-Negative Bacteria: An Expert Panel Opinion

Antimicrobial resistance represents a serious threat for global health, causing an unacceptable burden in terms of morbidity, mortality and healthcare costs. In particular, in 2017, carbapenem-resistant organisms were listed by the WHO among the group of pathogens for which novel treatment strategie...

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Published in:Antibiotics (Basel) 2022-09, Vol.11 (9), p.1263
Main Authors: Coppola, Nicola, Maraolo, Alberto Enrico, Onorato, Lorenzo, Scotto, Riccardo, Calò, Federica, Atripaldi, Luigi, Borrelli, Anna, Corcione, Antonio, De Cristofaro, Maria Giovanna, Durante-Mangoni, Emanuele, Filippelli, Amelia, Franci, Gianluigi, Galdo, Maria, Guglielmi, Gaspare, Pagliano, Pasquale, Perrella, Alessandro, Piazza, Ornella, Picardi, Marco, Punzi, Rodolfo, Trama, Ugo, Gentile, Ivan
Format: Article
Language:English
Subjects:
Acinetobacter baumannii
Algorithms
Antibacterial agents
Antibiotics
Antimicrobial agents
Antimicrobial resistance
Bacteria
carbapenem-resistant organisms
Disease prevention
Drug resistance
Drug resistance in microorganisms
Eastern Europe
Enterobacterales
Enzymes
Epidemiology
FDA approval
Genes
Global health
Gram-negative bacteria
Health aspects
Health care
Health risks
Health services
Infections
Infectious diseases
Intensive care
Medical care, Cost of
Morbidity
Mortality
Pandemics
Pathogens
Pneumonia
Pseudomonas aeruginosa
Public health
Review
Severe acute respiratory syndrome coronavirus 2
Stenotrophomonas maltophilia
Tetracycline
Tetracyclines
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Summary:Antimicrobial resistance represents a serious threat for global health, causing an unacceptable burden in terms of morbidity, mortality and healthcare costs. In particular, in 2017, carbapenem-resistant organisms were listed by the WHO among the group of pathogens for which novel treatment strategies are urgently needed. Fortunately, several drugs and combinations have been introduced in recent years to treat multi-drug-resistant (MDR) bacteria. However, a correct use of these molecules is needed to preserve their efficacy. In the present paper, we will provide an overview on the epidemiology and mechanisms of resistance of the most common MDR Gram-negative bacteria, proposing a treatment algorithm for the management of infections due to carbapenem-resistant bacteria based on the most recent clinical evidence.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics11091263