Morphological and Behavioral Effects in Zebrafish Embryos after Exposure to Smoke Dyes

Solvent Violet 47 (SV47) and Disperse Blue 14 (DB14) are two anthraquinone dyes that were previously used in different formulations for the production of violet-colored smoke. Both dyes have shown potential for toxicity; however, there is no comprehensive understanding of their effects. Zebrafish em...

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Bibliographic Details
Published in:Toxics (Basel) 2021-01, Vol.9 (1), p.9
Main Authors: To, Kimberly T, St Mary, Lindsey, Wooley, Allyson H, Wilbanks, Mitchell S, Bednar, Anthony J, Perkins, Edward J, Truong, Lisa, Tanguay, Robyn L, Garcia-Reyero, Natàlia
Format: Article
Language:English
Subjects:
Anthraquinone
Anthraquinone dyes
Autism
Automation
behavior
Blood-brain barrier
Disperse Blue 14
Dyes
Edema
Effluents
Embryos
Exposure
Fertilization
Jaw
Laboratories
Mortality
Nervous system
Neurotoxicity
Permeability
Smoke
Solvent Violet 47
Textiles
Toxicity
Zebrafish
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Summary:Solvent Violet 47 (SV47) and Disperse Blue 14 (DB14) are two anthraquinone dyes that were previously used in different formulations for the production of violet-colored smoke. Both dyes have shown potential for toxicity; however, there is no comprehensive understanding of their effects. Zebrafish embryos were exposed to SV47 or DB14 from 6 to 120 h post fertilization (hpf) to assess the dyes' potential adverse effects on developing embryos. The potential ability of both dyes to cross the blood-brain barrier was also assessed. At concentrations between 0.55 and 5.23 mg/L, SV47 showed a dose-dependent increase in mortality, jaw malformation, axis curvature, and edemas. At concentrations between 0.15 and 7.54 mg/L, DB14 did not have this same dose-dependence but had similar morphological outcomes at the highest doses. Nevertheless, while SV47 showed significant mortality from 4.20 mg/L, there was no significant mortality on embryos exposed to DB14. Regardless, decreased locomotor movement was observed at all concentrations of DB14, suggesting an adverse neurodevelopmental effect. Overall, our results showed that at similar concentrations, SV47 and DB14 caused different types of phenotypic effects in zebrafish embryos.
ISSN:2305-6304
2305-6304
DOI:10.3390/toxics9010009