Thermodynamics of ABC transporters

ABC transporters form the largest of all transporter families, and their structural study has made tremen- dous progress over recent years. However, despite such advances, the precise mechanisms that determine the energy-coupling between ATP hydrolysis and the con- formational changes following subs...

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Bibliographic Details
Published in:Protein & cell 2016-01, Vol.7 (1), p.17-27
Main Authors: Zhang, Xuejun C., Han, Lei, Zhao, Yan
Format: Article
Language:English
Subjects:
ABC
ABC transporters
Adenosine Triphosphate - metabolism
Animals
ATP
ATP-Binding Cassette Transporters - physiology
Biochemistry
Biomedical and Life Sciences
Cell Biology
Developmental Biology
differential-binding energy
elastic conformational energy
energy-coupling
Human Genetics
Humans
Life Sciences
Models, Theoretical
Protein Science
Review
Stem Cells
Thermodynamics
作业成本法
底物结合
热力学分析
结构分析
能量耦合
转运蛋白
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Summary:ABC transporters form the largest of all transporter families, and their structural study has made tremen- dous progress over recent years. However, despite such advances, the precise mechanisms that determine the energy-coupling between ATP hydrolysis and the con- formational changes following substrate binding remain to be elucidated. Here, we present our thermodynamic analysis for both ABC importers and exporters, and introduce the two new concepts of differential-binding energy and elastic conformational energy into the dis- cussion. We hope that the structural analysis of ABC transporters will henceforth take thermodynamic aspects of transport mechanisms into account as well.
ISSN:1674-800X
1674-8018
DOI:10.1007/s13238-015-0211-z