Mannitol-Enhanced Delivery of Stem Cells and Their Growth Factors across the Blood–Brain Barrier

Ischemic brain injury in adults and neonates is a significant clinical problem with limited therapeutic interventions. Currently, clinicians have only tPA available for stroke treatment and hypothermia for cerebral palsy. Owing to the lack of treatment options, there is a need for novel treatments s...

Full description

Saved in:
Bibliographic Details
Published in:Cell Transplantation 2014-01, Vol.23 (4-5), p.531-539
Main Authors: Gonzales-Portillo, Gabriel S., Sanberg, Paul R., Franzblau, Max, Gonzales-Portillo, Chiara, Diamandis, Theo, Staples, Meaghan, Sanberg, Cyndy D., Borlongan, Cesar V.
Format: Article
Language:English
Subjects:
Animals
Blood-Brain Barrier - drug effects
Blood-Brain Barrier - metabolism
Cord Blood Stem Cell Transplantation
Humans
Ischemia - therapy
Mannitol - chemistry
Mannitol - pharmacology
Nerve Growth Factors - pharmacology
Stem Cell Transplantation
Stem Cells - chemistry
Stem Cells - cytology
Stroke - therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ischemic brain injury in adults and neonates is a significant clinical problem with limited therapeutic interventions. Currently, clinicians have only tPA available for stroke treatment and hypothermia for cerebral palsy. Owing to the lack of treatment options, there is a need for novel treatments such as stem cell therapy. Various stem cells including cells from embryo, fetus, perinatal, and adult tissues have proved effective in preclinical and small clinical trials. However, a limiting factor in the success of these treatments is the delivery of the cells and their by-products (neurotrophic factors) into the injured brain. We have demonstrated that mannitol, a drug with the potential to transiently open the blood–brain barrier and facilitate the entry of stem cells and trophic factors, as a solution to the delivery problem. The combination of stem cell therapy and mannitol may improve therapeutic outcomes in adult stroke and neonatal cerebral palsy.
ISSN:0963-6897
1555-3892
DOI:10.3727/096368914X678337