11B NMR of the Morphological Evolution of Traditional Chinese Medicine Borax

This article applies nuclear magnetic resonance technology to the study of boron-containing traditional Chinese medicine, in order to explore the morphological evolution of boron elements in traditional Chinese medicine. Borax is a traditional Chinese medicine with anti-corrosion, anti-inflammatory,...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2024-01, Vol.29 (1), p.251
Main Authors: Li, Qiulin, Yang, Yawen, Wang, Qingfeng, Han, Xiang, Zhu, Junfeng, Zhang, Nan, Wang, Qiuhong, Li, Kanshe, Gong, Pin, Chen, Fuxin
Format: Article
Language:English
Subjects:
11B NMR
Acids
borax
boric acid
Boron
boron-containing compound
boron-containing TCM
Chinese medicine
Drug dosages
Ingredients
Medical research
Morphology
NMR
Nuclear magnetic resonance
Prescriptions
R&D
Research & development
Research methodology
Spectrum analysis
Sperm
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Summary:This article applies nuclear magnetic resonance technology to the study of boron-containing traditional Chinese medicine, in order to explore the morphological evolution of boron elements in traditional Chinese medicine. Borax is a traditional Chinese medicine with anti-corrosion, anti-inflammatory, antibacterial, and anticonvulsant effects. It is made by boiling, removing stones, and drying borax minerals like borate salts. This article introduces an 11B nuclear magnetic resonance method for identifying and characterizing boron-containing compounds in TCM. We applied this technology to borax aqueous solutions in different chemical environments and found that with boron mixed in the form of SP2 hybridization in equilateral triangles and SP3 hybridization in equilateral tetrahedra, the pH changes in alkaline environments significantly affected the ratio of the two. At the same time, it was found that in addition to the raw material peak, boron signals of other boron-containing compounds were also detected in 20 commercially available boron-containing TCM preparations. These new boron-containing compounds may be true pharmaceutical active ingredients, and adding them directly to the formula can improve quality and safety. This article describes the detection of 11B NMR in boron-containing traditional Chinese medicine preparations. It is simple, non-destructive, and can provide chemical fingerprint studies for boron-containing traditional Chinese medicine.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29010251