Radiation therapy for patients with brain metastases from non-small cell lung cancer without driven gene mutation

[1] For patients with epidermal growth factor receptor mutations or anaplastic lymphoma kinase gene rearrangements, corresponding agents have been approved for treatment. Studies have demonstrated that hippocampal-sparing WBRT (HS-WBRT) with simultaneous integrated boost (SIB) has the ability to avo...

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Bibliographic Details
Published in:Chinese medical journal 2020-10, Vol.133 (19), p.2359-2361
Main Authors: Li, Pei-Jie, Luo, Jie, Liu, Guang-E, Liu, Da-Hai, Shen, Sha-Sha, Li, Xin-Juan, Ma, Hu
Format: Article
Language:English
Subjects:
Brain cancer
Brain Neoplasms - genetics
Brain Neoplasms - radiotherapy
Cancer therapies
Carcinoma, Non-Small-Cell Lung - genetics
Chemotherapy
Clinical trials
Humans
Immunotherapy
Lung cancer
Lung Neoplasms - genetics
Medical Progress
Metastasis
Mutation
Oncology
Radiation therapy
Tumors
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Summary:[1] For patients with epidermal growth factor receptor mutations or anaplastic lymphoma kinase gene rearrangements, corresponding agents have been approved for treatment. Studies have demonstrated that hippocampal-sparing WBRT (HS-WBRT) with simultaneous integrated boost (SIB) has the ability to avoid declines in neurocognitive function and increase the local control rate (LCR): with a 1-year intracranial LCR of 67%, only mild adverse effects are observed after radiation therapy. [...]we summarized the main radiotherapy modes for BM from NSCLC in this article [Table 1].
ISSN:0366-6999
2542-5641
DOI:10.1097/CM9.0000000000001044